Why is domestic Xinguan oral medicine a drug for the treatment of AIDS

Jin Lei Alex From the Aofei temple
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friend , Treat the new crown , immediately Oral tablets That's it .

You heard me .

The latest heavy news released by the State Food and Drug Administration shows ：

The first domestic anti Xinguan oral drug has been approved for marketing ！

But what is more surprising is ——

This oral medicine , Azvidin , It was originally used for treatment AIDS Drugs （ Selling price of each piece 25.86 element ）.

And from the published clinical trial results , This oral medicine can be used in 5 Days or so In time , Achieve the effect of virus elimination .

So here comes the question ：

Why can AIDS drugs cure covid-19 ？

Azivudine is an oral two target nucleoside antiviral drug .

At first , It was invented as a new drug for the treatment of AIDS .

Its principle , yes By suppressing HIV、HCV、EV71 and HBV etc. RNA Virus replication , To achieve antiviral effect .

And novel coronavirus , It is also a typical RNA Viruses .

So as early as the outbreak of the epidemic , Someone has put the hope of treating the new crown , On azvedine ：

At that time, some antiviral drugs were screened , Put into the front-line work of treating the new crown , This includes azivudine .

According to the official website of China Clinical Trial Center ,2020 year 2 month 15 Japan , One is entitled 《 A randomized trial of azivudine tablets in the treatment of covid-19 infection with pneumonia 、 to open up 、 Controlled clinical trial 》 Registered successfully .

And in the same year 7 month , Henan Normal University Professor Chang Junbiao The team of Advanced Science A related study was published on ：

This study has a total of 20 A preliminary clinical trial was carried out in patients with mild and common neocoronavirus , Results show ：

Azivudine is effective in patients with mild covid-19 and ordinary patients .

To be specific , The average time of first nucleic acid negative conversion in patients treated with azvudine was 2.6 God , The average time for patients in the control group receiving the standard treatment regimen to achieve this result is 5.6 God .

And there were no adverse reactions in the treated group , But the control group has 3 An adverse reaction .

Regarding this , To explain it in the words of Professor Chang Junbiao is ：

Azvudine as a virus suppressor RNA Dependence RNA Polymerase （RdRp） Nucleoside analogues , It can specifically act on covid-19 RdRp, So as to inhibit virus replication , Its drug targeting is strong .

Same year 10 month , Professor Chang Junbiao's team is still Nature Research related to azvudine was published in the sub journal ：

The result of this experiment is also ideal ——

In the experimental group 10 Patients , stay 4 In days , The first nucleic acid negative conversion rate reached 90%; In the same case, the control group , Only for 10%.

And there is another patient , In hospital 20 Without fruit , The first day after taking azvudine 5 It turns overcast .

besides , In this year 4 At the China Pharmaceutical Development Conference in August , Chinese Academy of Engineering Academician Jiang Jiandong The effect of azvudine is also summarized ：

Oral medication 3-4 Day nucleic acid turns negative

Average medication time 6-7 God

Average 9 Days after discharge

△ Picture source ： The Internet , Academician Jiang Jiandong made a speech

And academician Jiang Jiandong also mentioned , As early as 2020 year 2 Azvudine was found to be able to treat the new crown , It has been approved by the State Food and Drug Administration of China , Phase III clinical trials can be carried out .

now , The results of the phase III clinical trial have been published , In terms of results ：

Azivudine tablets can significantly shorten the time of symptom improvement in patients with moderate covid-19 infection with pneumonia , Increase the proportion of patients with improved clinical symptoms , Achieve clinical excellent results .

After the first administration 7 The proportion of subjects with improved clinical symptoms within days in azvudine Group 40.43%, Placebo group 10.87%（P value <0.001）, The median time for the improvement of clinical symptoms of the subjects was significantly different between the azvudine group and the placebo group （P value <0.001）.

Azvudine can inhibit the activity of covid-19 virus , The virus removal time is 5 Days or so .

But so far Clinicaltrials.gov Displayed on the , The final clinical results of the three registered studies of azvudine in the treatment of neocoronas have not been published .

R & D team from Henan

except “ The first domestic oral neocrown drug ” outside , The R & D team behind it has also become the focus of attention this time .

According to the news released by the State Food and drug administration , The team is from Henan Real creatures Technology Co., Ltd , Founded on 2012 year 9 month 12 Japan .

And before the SFDA released the news , Real creatures in 7 month 15 It has submitted its marketing application for azivudine to treat the indications of covid-19 .

After conditional approval , This means that the real organism has become the first domestic manufacturer of new coronal oral medicine .

According to the 《 henan daily 》 news ：

at present , Azivudine starts from R & D 、 API production 、 Preparation production , The whole industrial chain, including the sales headquarters, has the basic conditions for landing in Henan .

And then focus on the drug itself , Its inventor is Professor Chang Junbiao of Henan Normal University .

Later, the drug was made by real creatures 、 Zhengzhou University 、 Henan Normal University 、 High tech research center of Henan Academy of Sciences jointly developed .

However, the intellectual property rights of azvidin , It belongs to real creatures .

△ Professor Chang Junbiao , Picture source ： The Internet

But if we delve into its origin , It goes back to the last century 90 years .

At that time, because the plasma gap was relatively large , But because the operation is not standardized , Causing tens of thousands of people infected with AIDS .

At that time, there was no independently developed drug for the treatment of AIDS , Patients often have to rely on imported drugs , Not only is it expensive , It is often accompanied by side effects .

So in 2004 year , Professor Chang Junbiao's team began to work on this .

But the research and development process is not only long and repetitive , The requirements for the experimental environment are also extremely harsh , The input cost is self-evident .

Fortunately 2012 Professor Chang Junbiao's team is supported by real creatures , Exclusive investment in the research and development of azvudine .

Finally, after three clinical trials , Azivudine was finally available .

One More Thing

In just , Tsinghua University Good news has also been announced here ：

Lead the research and development of the first domestic covid-19 neutralizing antibody drug ！

According to Tsinghua , The drug can be used to treat mild and common types with progression to severe （ Including hospitalization or death ） Adults and adolescents with high risk factors （12-17 year , weight ≥40kg） Patients with covid-19 infection .

And the National Health Commission has been in this year 3 month 15 Japan , Incorporate this drug into 《 New Coronavirus pneumonia diagnosis and treatment plan （ Trial version 9 ）》, For the treatment of anti covid-19 pneumonia .

Reference link ：
[1]https://www.zhihu.com/question/545252149
[2]https://pubmed.ncbi.nlm.nih.gov/32837847/
[3]https://finance.sina.com.cn/jjxw/2022-07-26/doc-imizirav5397256.shtml
[4]https://mp.weixin.qq.com/s/BhoBzWIevpCThFYrW3U4BQ
[5]https://m.thepaper.cn/baijiahao_19008477