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PNA modified polypeptide BZ Val Gly Arg PNA | BOC Val Leu Gly Arg PNA
2022-07-23 09:39:00 【Meet Qi Yue】
PNA Modified polypeptide Bz-Val-Gly-Arg-PNA|Boc-Val-Leu-Gly-Arg-PNA
Peptide nucleic acid (PNA,peptidenucleicacid) It's a kind of DNA Analogues , Can identify and combine DNA or RNA Sequence , Form a stable double helix structure . because PNA No negative charge , And DNA and RNA There is no electrostatic repulsion between , Therefore, the stability and specificity of the binding are greatly improved and are not hydrolyzed by nuclease and protease .
PNA Can pass Watson-Crick The form of base pairing is recognized and combined DNA or RNA Sequence , Form a stable double helix structure . because PNA No negative charge , And DNA and RNA There is no electrostatic repulsion between , Therefore, the stability and specificity of binding are greatly improved ; differ DNA or DNA、RNA Interbreeding ,PNA And DNA or RNA The hybridization of is hardly affected by the salt concentration of the hybrid system , And DNA or RNA The hybridization ability of molecules is far better than DNA/DNA or DNA/RNA, It shows high hybridization stability 、 Excellent specific sequence recognition ability 、 Not hydrolyzed by nuclease and protease .

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Small make up axc,2022.07.20
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