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肽核酸(PNA)偶联穿膜肽(CCPs)(KFF)3K形成CCPs-PNA|肽核酸的使用方法
2022-07-23 01:34:00 【遇见齐岳】
肽核酸(PNA)偶联穿膜肽(CCPs)(KFF)3K形成CCPs-PNA|肽核酸的使用方法
肽核酸(PNA,peptidenucleicacid)是一种DNA类似物,该分子的特点是以中性的肽链酰胺2-氨基乙基甘氨酸键取代了DNA中的戊糖磷酸二酯键骨架,其余的与DNA相同。PNA可以通过Watson-Crick碱基配对的形式识别并结合DNA或RNA序列,形成稳定的双螺旋结构。由于PNA不带负电荷,与DNA和RNA之间不存在静电斥力,因而结合的稳定性和特异性都大为提高;不同于DNA或DNA、RNA间的杂交,PNA与DNA或RNA的杂交几乎不受杂交体系盐浓度影响,与DNA或RNA分子的杂交能力远远优于DNA/DNA或DNA/RNA。

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小编axc,2022.07.20
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