Methods of using tyrosine modified peptide nucleic acid PNA | Tyr PNA | BZ Tyr PNA | 99Tcm survivinmrna antisense peptide nucleic acid

Tyrosine modified peptide nucleic acid PNA|Tyr-PNA|Bz-Tyr-PNA|99Tcm—survivinmRNA Methods of using antisense peptide nucleic acid

Peptide nucleic acid (Peptide Nucleic Acid,PNA)   It is a kind of synthetic, similar to DNA or RNA The polymer of . Similar to polypeptides , Various purine and pyrimidine bases are connected to the backbone by methylene carbonyl . because PNA No negative charge , And DNA and RNA There is no electrostatic repulsion between , Therefore, the stability and specificity of binding are greatly improved . It's not easy to be DNA Enzyme and protease hydrolysis ,PNA Extremely stable in vivo and in vitro .

Connectors that may be used

linker ( Also known as AEEA or eg1)： Commonly used to improve solubility

Play the role of space separation ：O、E、X、C3、C4、C6、C12

Sulfhydryl addition ：C6SH、C11SH

 

Peptide nucleic acid pna Custom products ：

Sulfhydryl functionalized peptide nucleic acid PNA
NH2-PNA
COOH-PNA
MAL-PNA
NHS-PNA
N3-PNA
Alkyne-PNA
SH-PNA
Hydrazide-PNA
Biotin-PNA
CHO-PNA
OH-PNA
VA-PNA
PYR-PNA Mark FITC Fluorescent groups
HiLyte Fluor 488 Mark PNAs Peptide nucleic acid
Methoxycoumarin labeled peptide nucleic acid PNA
Dansulfonyl chloride labeled peptide nucleic acid PNA
AMC Labeled peptide nucleic acid PNA
Aminocoumarin labeled peptide nucleic acid PNA

Qi Yue bio Small make up axc.2020.07.19