PNA PNA modified polypeptide bz- (DL) - Arg PNA | z-ala-ala-leu-pna | suc ala ala ala PNA

PNA Peptide nucleic acid modifies polypeptide Bz-(DL)-Arg-pNA|Z-Ala-Ala-Leu-pNA|Suc-Ala-Ala-Ala-pNA

Peptide nucleic acid (PeptideNucleicAcid,PNA) It's a kind of DNA Analogues , Structurally, it retains DNA Base and deoxyribose , Just the original ribose - The phosphate skeleton is replaced by an amide bond skeleton similar to a peptide bond . therefore ,PNA Still follow the principle of complementary base pairing , And the skeleton turns from negative to nearly neutral , Weakened the electrostatic repulsion between double stranded nucleic acids , bring LNA And DNA or RNA The binding stability and specificity of are greatly improved . and ,PNA The amide bond skeleton of is not easy to be hydrolyzed by nuclease and protease , Make it stable in vivo and in vitro .

 

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Small make up axc,2022.07.20