PNA modified polypeptide arms PNA PNA DNA suc aapf PNA suc - (ALA) 3 PNA

PNA Modified polypeptide ARMS-PNA|PNA-DNA|suc-AAPF-pNA|Suc-(Ala)3-pNA

PNA（Peptidenucleicacid, Peptide nucleic acid ） It is a kind of synthetic, similar to DNA,RNA Of chemicals .PNA The skeleton of is made of repetition N-2-( Aminoethyl )- Glycine is the unit , Through peptide bond combination . The base and the skeleton are connected by a methylene carboxy bond . Similar to polypeptides ,PNA Also have N End sum C End difference . At the same time as PNA Nothing like DNA,RNA The phosphate group on , therefore PNA And DNA,RNA Lack of electrical repulsion between , The bonding strength between the two is greater than DNA And DNA A combination of . because PNA Neither belongs to polypeptide , Nor does it belong to nucleic acid , therefore ,PNA It is not easy to be hydrolyzed by protease or nuclease , Whether in vivo or in vitro ,PNA Are fairly stable , meanwhile , Due to the strong specificity of pairing between bases , High thermal stability .

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Small make up axc,2022.07.20