Near infrared two region agzs quantum dots wrapped deoxyribonucleic acid dna|dna agzsqds (Qiyue)

Near infrared region II AgzS Quantum dots wrap deoxyribonucleic acid DNA|DNA-AgzSQDs（ Qi Yue ）

DNA It is an important carrier of biological genetic material , It is an important polymer in Biology , It plays a very important role in the process of biological evolution .DNA The structure of contains the determination of heredity 、 cell division 、 The differentiation of 、 Information about life processes such as growth and protein synthesis .

form DNA The four basic bases of are ： Guanine （G）、 cytosine （C）、 adenine （A）、 Thymine （T）. stay DNA In the double helix structure of ,A And T Complementary pairing ,G And C Complementary pairing , This is based on the principle of complementary base pairing . Paired bases are connected by hydrogen bonds ,A and T Two hydrogen bonds are formed between ,G and C Three hydrogen bonds are formed between .DNA In addition to four basic bases , There are also many “ Rare base ”, They are chemical modification products of bases , Most of these bases are methylated modified bases .DNA Methylation （DNAmethylation） It is one of the early discovered methods of gene epigenetic modification , Referring to DNA Methyltransferase （DNMT） Under catalysis , With S- Adenosylmethionine （s-adenosylmethionine,SAM） Methyl donor , Transfer the active methyl group to DNA The chemical modification process on a specific base in the chain . such DNA The modification did not change the gene sequence , But it can turn off the activity of some genes , Demethylation may induce gene reactivation and expression .DNA Methylation mainly occurs in 5’-CpG-3’（ cytosine - Phosphate - Guanine sequence ） Of C On , Methyltransferase ( Such as DNMT1) Which can transfer methyl groups to cytosine bases C5 site , The base formed is “5- Methylcytosine （5-methylcytosine）”, abbreviation 5mC, It is also called the fifth base （ Pictured 1.2 Shown ）. besides , Methylated bases also contain 5hmC、5fC、5caC etc. .

 

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Small make up axc,2022.07.26