Synthesis route of ALA PNA alanine modified PNA peptide nucleic acid | AC ala PNA

Ala-PNA Alanine modification PNA Peptide nucleic acid |Ac-Ala-PNA The synthetic route of

PNA（Peptide nucleic acid, Peptide nucleic acid ） It is a kind of synthetic, similar to DNA,RNA Of chemicals .PNA The skeleton of is made of repetition N-2-( Aminoethyl )- Glycine is the unit , Through peptide bond combination . The base and the skeleton are connected by a methylene carboxy bond . Similar to polypeptides ,PNA Also have N End sum C End difference . At the same time as PNA Nothing like DNA,RNA The phosphate group on , therefore PNA And DNA,RNA Lack of electrical repulsion between , The bonding strength between the two is greater than DNA And DNA A combination of . because PNA Neither belongs to polypeptide , Nor does it belong to nucleic acid , therefore ,PNA It is not easy to be hydrolyzed by protease or nuclease , Whether in vivo or in vitro ,PNA Are fairly stable , meanwhile , Because the pairing specificity between bases is very strong , High thermal stability .

 

Peptide nucleic acid pna Custom products ：

Leucine coupling PNA Peptide nucleic acid
Valine modified peptide nucleic acid PNA
Alanine modification PNA Peptide nucleic acid
Arginine modified polypeptide nucleic acid PNA
Lysine coupled peptide nucleic acid PNA
Aspartic acid modification PNA Peptide nucleic acid
Isoleucine modified peptide nucleic acid
Serine modified polypeptide nucleic acid PNA
Threonine modified peptide nucleic acid PNA
Glutamic acid coupling PNA Peptide nucleic acid
Methionine modified peptide nucleic acid
Phenylalanine coupled peptide nucleic acid PNA
Proline modification PNA Peptide nucleic acid

Qi Yue bio Small make up axc.2020.07.19