Biovendor sRAGE antibody solution

Clinically ,sRAGE Decreased levels are markers of loss or imbalance of inflammatory control , Related to cardiovascular disease . In patients with hypertension ,sRAGE Levels are negatively correlated with blood pressure . And in the serum of patients with end-stage renal disease and acute lung injury ,sRAGE The level rises obviously .

sRAGE

Soluble advanced glycation end products receptor ;  Soluble advanced glycation end products receptor ;  Product receptors ;  Soluble advanced glycation end products receptor ;  Soluble glycation end products receptor .

AI Meijie  BioVendor sRAGE antibody turn Academic nature ：

type ： Polyclonal antibody

Other names ： Soluble receptors for advanced glycation end products ,sRAGE, Advanced glycation end products specific receptors ,AGER,RAGE

species ： human beings

application ： Western blotting 、ELISA

Antigen source ： E. coli

By using recombiners  sRAGE  Immunity produces antibodies in sheep .

Amino acid sequence ： Immune antigens  (36.5 kDa)  It 's a protein , contain  325  individual  AA  Recombiner  sRAGE  and  14  An extra  AA,N  End  His-tag（ highlight ）.

Purification method ： In immobilizing recombiners  sRAGE  Immunoaffinity chromatography was performed on the column .

Antibody content ：0.1mg（BCA Method determination , With BSA As the standard ）

The formula ： Antibodies are  0.05 M  Phosphate buffer 、0.1 M NaCl、pH 7.2  Medium freeze-drying . No azide .

restructuring ： Join in  0.2 ml  Deionized water , Allow the lyophilized particles to dissolve completely . Slight turbidity may occur after re dissolution , Does not affect antibody activity . under these circumstances , Clarify the solution by centrifugation .

Storage / expire ： Lyophilized antibody in –20°C  It remains stable and fully active when stored under the , Until the expiry date . Repack the product after reconstruction to avoid repeated freeze-thaw cycle , And in –80°C  Under freezing storage . The recombinant antibody can be used in  4°C  Next save for a while ; stay  4°C  Next  1  The activity did not decrease after weeks .

Quality control testing : indirect  ELISA—— Determine antibody titer  SDS PAGE—— Determine antibody purity

* For research purposes only .

Research topic ：

Diabetes  -  Other related products 、 Neural tissue markers 、 lung disease 、 Kidney disease

According to the research topic ,BioVendor sRAGE Antibody related ：

Diabetes  -  Other related

Neural tissue markers

Lung disease

Kidney disease

 

AI Meijie  BioVendor sRAGE Antibody related literature ：

1、Brett J, Schmidt AM, Yan SD, Zou YS, Weidman E, Pinsky D, Nowygrod R, Neeper M, Przysiecki C, Shaw A, et al. Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues. Am J Pathol. 1993 Dec;143 (6):1699-712

2、Emanuele E, D'Angelo A, Tomaino C, Binetti G, Ghidoni R, Politi P, Bernardi L, Maletta R, Bruni AC, Geroldi D. Circulating levels of soluble receptor for advanced glycation end products in Alzheimer disease and vascular dementia. Arch Neurol. 2005 Nov;62 (11):1734-6

3、Falcone C, Emanuele E, D'Angelo A, Buzzi MP, Belvito C, Cuccia M, Geroldi D. Plasma levels of soluble receptor for advanced glycation end products and coronary artery disease in nondiabetic men. Arterioscler Thromb Vasc Biol. 2005 May;25 (5):1032-7