Preparation of peptide kc2s modified albumin nanoparticles / targeting peptide GX1 modified human serum albumin nanoparticles probe

The scientific research content shared today is Polypeptides KC2S Modified albumin nanoparticles / Targeting peptide GX1 Modified human serum albumin nanoparticle probe Research preparation , Watch it with Xiaobian ！

Ruixi Xiaobian recommends ： Targeting peptide GX1 Study on modified human serum albumin nanoparticles probe ：

Targeting peptide GX1 Modified human serum albumin (HSA) As indocyanine green (ICG) The carrier of , Synthetic near infrared fluorescent probe GX1-HSA-ICG, Study its targeted imaging ability as a near-infrared fluorescence probe .

Method : With HSA As ICG The carrier of , Through chemical modification and GX1 Covalent linkage , synthesis GX1-HSA-ICG Nanoparticle probe ; Use SDS-PAGE Identify the probe synthesis ; Using probe and umbilical vein endothelial cells HUVEC And umbilical vein endothelial cells co cultured with tumor cells Co-HUVEC Conduct binding and competitive inhibition tests , Verify probe and Co-HUVEC Specificity of cell binding

result : Successfully synthesized GX1-HSA-ICG. Cell binding and competitive inhibition experiments show GX1-HSA-ICG But with Co-HUVEC Cell specific binding ; In vivo imaging of tumor bearing mice also showed GX1-HSA-ICG a ICG Have longer circulation time in the body , And locally HSA-ICG There is stronger aggregation .

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RXYWX.2022.7.27