Metal organic framework MOF Al (Diba), MOF Zr (Diba), MOF Fe (Diba) loaded with curcumin / carboxybenzylpenicillin /mtx methotrexate / paclitaxel ptx/ DOX / cisplatin cddp/cpt camptothecin and other d

Metal organic framework MOF-Al(DIBA),MOF-Zr(DIBA),MOF-Fe(DIBA) Loaded with curcumin / Carboxybenzylpenicillin /MTX Methotrexate / Paclitaxel PTX/ Adriamycin DOX/ Cisplatin CDDP/CPT Camptothecin and other drugs

MOF-Al(DIBA) Loaded with curcumin ;MOF-Zr(DIBA) Loaded with curcumin ;MOF-Fe(DIBA) Loaded with curcumin

MOFs Materials have many unique characteristics , For example, ultra-low mass density （~0.13g cm-3）、 Large pore volume and clear pore size distribution . Even more remarkable , In recent years, there have been super high specific surface areas MOFs Synthesized , The specific surface area is about 10000 m2 g-1 Much higher than activated carbon and molecular sieve materials . Generally speaking ,MOFs The material is microporous , Its aperture is less than 2nm. By increasing the ligand length , People can make its aperture breakthrough 2nm.

MOFs Carrier material MOF-M(DTBA)(M=Fe,Al,Zr). Its ligand is 4,4'- Dithiophthalic acid (4,4'-DTBA), One of the disulfide bonds on the overexpression of glutathione in cancer cells (GSH) Restore responsiveness , stay GSH The ligand breaks under the stimulation of , So that MOF-M(DTBA) Carrier cleavage , Thus, the drug curcumin can be loaded (CCM) Rapid release at the tumor site , It's solved CCM Low bioavailability , unstable , Poor water solubility .

 

[email protected]@ZIF-8 Nanoparticles loaded adriamycin (DOX)

ZIF-8/ Graphene composite nanoparticles (ZIF-8/GQDs) Loading adriamycin (DOX)

nanometer ZIF-90 Adriamycin encapsulated (DOX)

[email protected]/Zn-ZIF-H Adriamycin was encapsulated in the composite (DOX)

ZIF-8 Loading adriamycin (DOX)

[email protected] Paclitaxel loaded PTX

[email protected] Loading adriamycin DOX

Urease coated ZIF-8

ZIF-8 Loading insulin

FITC- Insulin /GOx Loaded ZIF-8

FA-CHI-5-FAM Covering load 5-FU Hollow of ZIF-8

ZIF-8/[email protected]

Machine frame ZIF- 8 Small molecule drugs

The above information comes from Xiaobian axc,2022.06.10