Near infrared dye cy7.5 labeling PNA polypeptide experimental steps cy7.5-pna|188re labeling anti gene peptide nucleic acid (agpna)

Near infrared dye CY7.5 Mark PNA Polypeptide experiment steps CY7.5-PNA|188Re Tag anti gene peptide nucleic acid (AGPNA)

Peptide nucleic acid , Also known as PNA (Peptide Nucleic Acid), yes - A class of novel nucleic acid analogues , Its characteristics are : 1. The ability of writing with nucleic acids is stronger than that of hybridization between nucleic acids ; 2. The thermal stability is higher than that of hybrids between nucleic acids ; 3. The anti enzymatic hydrolysis ability is enhanced , Because of its non peptide and non nucleic acid structural characteristics , Neither protease nor nuclease can degrade peptide nucleic acid (PNA). at present , Peptide nucleic acid (PNA) It is widely used in Chemistry 、 biology 、 Antisense drugs 、 Molecular recognition 、 Genetic diagnosis and other fields . At present, many non classical peptide nucleic acids are also developed , Such as gamma-PN etc. .

 

The role of fluorescent labeling

  Study on the function of fluorescent marker in protein 、 Drug screening and other fields are also widely used . People use fluorescent labeled peptides to detect the activity of target proteins , The developed high-throughput activity screening method is applied to drug screening and drug development of disease treatment target proteins （ for example , Various kinases 、 Phosphatase 、 Peptidase, etc ）. therefore , Fluorescent modification of polypeptides , It is also an important content in the field of peptide synthesis .

About peptide nucleic acid synthesis :

1. Composite content : Conventional synthesis 、 Special peptide nucleic acid synthesis , Such as Telomere FISH , gamma-PNA etc. ;
2. PNA modification : Fluorescent modification 、 Biotin modification 、 Polypeptide modification 、 Glycosylation and DNA Embellishment, etc , If the customer needs to decorate in other aspects , Can be proposed , We will try our best to meet its research needs .
3. Synthetic scale : The conventional synthesis scale is : 50 And 100nmole , Purity is usually >90% , Free collection c. Synthetic scale : The conventional synthesis scale is : 50 And 100nmole , Purity is usually >90% , Free delivery can also be determined according to customer requirements .

Peptide nucleic acid pna Custom products ：

Lysine coupled peptide nucleic acid PNA
Aspartic acid modification PNA Peptide nucleic acid
Isoleucine modified peptide nucleic acid
Serine modified polypeptide nucleic acid PNA
Threonine modified peptide nucleic acid PNA
Glutamic acid coupling PNA Peptide nucleic acid
Methionine modified peptide nucleic acid
Phenylalanine coupled peptide nucleic acid PNA
Proline modification PNA Peptide nucleic acid
Histidine modified peptide nucleic acid
PNA Peptide nucleic acid modified nano materials
Isotope labeled peptide nucleic acid PNA
177Lu-DOTA-anti-bcl-2-PNA-Tyr3-octreotate
Cell penetrating peptide ( CPPs) Coupled peptide nucleic acid
Tos-Gly-Pro-Arg-pNA
D-Phe-Pip-Arg-pNA
Chromogenic tripeptide CBZ-gly-pro-arg-pNA
Z-Gly-Pro-pNA
Boc-Val-Leu-Gly-Arg-PNA
Bz-Val-Gly-Arg-PNA
Boc-Leu-Gly-Arg-PNA
Ile-Glu-Gly-Arg-pNA (S-2222)
Pro-Phe-Arg-pNA (S-2302)
Ac-Phe-Gly-PNA
Dnp-Gly-X-L-Pro-Gly-pNA
2-Ala-Ala-LeupNA
Suc-Ala-Ala-pNA
Arg-His-Gly-[TACCTAGCAT]PNA-Arg-CONH2

Qi Yue bio Small make up axc.2020.07.19