PNA PNA custom service | PNA clamp PCR (pna-pcr) | cgappna multivalent PNA ligand

pna Peptide nucleic acid customization service | Peptide nucleic acid clamp -PCR(PNA-PCR)|cGAPPNA Multivalent peptide nucleic acid ligands

Peptide nucleic acid (PeptideNucleicAcid,PNA) It's something like DNA or RNA The polymer of . Similar to polypeptides , Various purine and pyrimidine bases are connected to the backbone by methylene carbonyl . because PNA No negative charge , And DNA and RNA There is no electrostatic repulsion between , Therefore, the stability and specificity of binding are greatly improved . It's not easy to be DNA Enzyme and protease hydrolysis ,PNA It is stable in vivo and in vitro .

 

PNA The main application of

Sequence specific PCR（PNA clip ）

Telomeres 、 Centromere FISH probe , Gene specific probes , Infection test

Antisense / Antimicrobial agents

miRNA

Double chain DNA Intrusion and capture

Microarray probe .

Mark PNA Introduction of peptide nucleic acid

PNA chain 5’ End sum 3’ Both ends can be marked . because 3' The terminal is an inactive group (-CONH2), So you need to add a lysine , The amino group on its side chain can be used to mark .

If in 5' End marker , We suggest that PNA Add 1-2Olinkers.

Marker ： Fluorescent groups （—NHS Ester or carboxyl amide ）、 Biotin 、 Palmitic acid 、 Digoxin 、DABCYL、 Azide 、 Methylene blue 、 Sulfhydryl, etc .

Related products

Ala-Ala-Phe-pNA
Suc-Ala-Xaa-cis-Pro-Phe-pNA
Suc-Ala-Ala-cis-Pro-Phe-pNA
Suc-Ala-Gly-cis-Pro-Phe-pNA
Suc-Ala-Phe-Pro-Phe-pNA
Meo-Suc-Arg-Pro-Tyr-pNA
Suc-Ala-Tyr-Leu-Val-pNA
N-Suc-Ala-Ala-Pro-Phe-pNA
Suc-Ala-Gly-Pro-Phe-pNA
Small molecule tetrapeptide substrate Suc-AAPF-pNA
Suc-AAPL-pNA
Suc-AAPM-pNA
Suc-L-Tyr-D-Leu-D-Val-pNA
Suc-Phe-Pro-Phe-pNA
Suc-A-A-A-pNA
Suc-Ala-Ala-Pro-Glu-pNA
Suc-Ala-Ala-Ala-pNA
Z-Ala-Ala-Leu-pNA
Bz-(DL)-Arg-pNA
Suc-Ala-Glu-Pro-Phe-pNA
Suc-Ala-Pro-Ala-pNA
Pyr-Phe-Leu-pNA
Suc-Ala3-pNA
suc-Ala-Ala-Pro-Aaa-pNa
2022.07.18
Basics pna Peptide nucleic acid products
PNA Peptide nucleic acid modifies polypeptide
PNA Peptide nucleic acid coupled amino acid polypeptide
Peptidyl prolyl CIS trans isomerase
Contains azaphenylalanine derivatives Aphe-X-（4- Nitrophenyl ） Tripeptide of
Polypeptide modification PNA Peptide nucleic acid
Tripeptide p-nitroaniline PNA Peptide nucleic acid
Tripeptide p-nitroaniline PNA Peptide nucleic acid
Tripeptide p-nitroaniline PNA Peptide nucleic acid
Folic acid modification PNA Peptide nucleic acid
Functional peptide nucleic acid monomer

Small make up axc,2022.07.20