Qi Yue: thiol modified oligodna | DNA modified cdte/cds core-shell quantum dots | DNA coupled indium arsenide InAs quantum dots InAs DNA QDs

Qi Yue ： Thiol modified oligomer DNA|DNA modification CdTe/CdS Core-shell quantum dots |DNA Coupled indium arsenide InAs Quantum dots InAs-DNA QDs

DNA modification （DNA modification） yes DNA After synthesis , Through a series of chemical processing, its structure changes . Such as DNA Methylation of .

DNA Structure

The primary structure

DNA The primary structure of , Refer to 4 The connection and sequence of nucleotides , It's time to DNA Chemical composition of molecules .

DNA The primary structure of determines its high-level structure , Such as B-DNA Zhongduo G-C The area is easy to form a left-handed spiral DNA（Z-DNA）, And reverse repeated DNA Clips are prone to hairpin structures . These high-level structures determine and affect the functions of the primary structure .

Secondary structure

DNA The secondary structure refers to the double helix structure generated by the reverse parallel winding of two polynucleotide chains .

Usually ,DNA The secondary structure of is divided into two categories ： One is right-handed spiral , Such as A-DNA and B-DNA,DNA It usually exists in the form of right-handed spiral ; The other is left-handed spiral , namely Z-DNA

Advanced structure

DNA Advanced structure of , Refer to DNA The double helix further twists and turns to form a more complex specific spatial structure , Including supercoils 、 Knots in linear double chains （kink）、 Multiple spirals, etc . among , The supercoiling structure is DNA The main form of high-level structure , It can be divided into positive supercoils （ Right hand supercoil ） And negative supercoil （ Left hand supercoil ） Two categories: , Negative supercoils are common in cells DNA Advanced structural form , A positive supercoil is an over twisted double helix . They can transform each other under the action of different types of topoisomerases or under special circumstances .

 

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Small make up axc,2022.07.25