Organic metal porous material MOF (FE) contains camptothecin, and gambogic acid and indocyanine green | rmof-3 contain paclitaxel

Organometallic porous materials MOF(Fe) Camptothecin encapsulated , Gambogic acid 、 Indocyanine green |RMOF-3 Paclitaxel loaded custom

MOF There are three main drug loading methods for materials ：

In situ encapsulation （ One step encapsulation method ）, Non in situ encapsulation method （ Two step encapsulation method ） And methods of using active molecules as ligands . In situ encapsulation method is to synthesize MOF The raw material of the material is put into the drug solution , stay MOF As the material is formed, the drug molecules are also sealed into its pores . Because the thermal stability of general drugs is poor and MOF It is difficult to synthesize the material in a concentrated solution , In situ synthesis is only applicable to some drugs with thermal stability and some special MOF material .

CD-MOF Loading ciprofloxacin

Metal organic frameworks MOF-5 Loading metronidazole

Eu-MOF Loaded with letitrexed

Metal organic frameworks MOF-199 Load pemetrexed

MOF-303 Loading anisamide

Tb-MOF Package load Ad Adamantane

Dy-MOF Azithromycin loaded

Loading anticancer prodrug adriamycin CIS aconitic acid (CAD) Form composite materials loaded with drugs ([email protected]@CAD)

Drug loaded particles [email protected]

[email protected]@DOTAP

Cationic lipid materials (2,3- Di oleoyl - Propyl )- Trimethylamine [DOTAP] The parcel [email protected]

Loading anticancer prodrug adriamycin CIS aconitic acid (CAD) Form composite materials loaded with drugs ([email protected]@CAD),

COF-5 load 5-Fu(5- Fluorouracil )

Covalent organic framework materials COF-105 Loaded methotrexate

COF-102 Loading adriamycin (DOX)

COF-300 Loading taxol

CCOF-1 Containing ibuprofen

  The above information comes from Xiaobian axc,2022.06.09