5,10-di (4-aminophenyl) - 15,20-diphenylporphyrin (cis-dadph2) /5,15-di (4-aminophenyl) - 10,20-diphenylporphyrin (trans-dadph2) / (tri-apph2) supplied by Qiyue

Porphyrins and their metal complexes are cytochromes 、 Heme, chlorophyll and other essential substances for organisms , It has played an important role in the progress of biology . porphyrin —CDs The study of supramolecular systems in gene immunoblotting 、 Controlled drug release 、 Chiral recognition 、 Molecular switches and mimetic enzymes have very broad application prospects . porphyrin —CDs The study on the inclusion mechanism of is becoming more and more perfect , The development of this field is bound to be beneficial to the life science 、 It has made great contributions to the research and development of medicine . This paper synthesized 5-（4- Nitrophenyl ）-10,15,20- Triphenyl porphyrin （NTPPH2） and 5-（4- Aminophenyl ）-10,15,20- Triphenyl porphyrin （ATPPH2）, The compounds were characterized in detail and their structures were confirmed . Using fluorescence spectrometry 、 Ultraviolet — Visible spectrophotometry was used to study NTPPH2、ATPPH2 Respectively with α-CD、β-CD and γ-CD The formation of supramolecular systems , The inclusion constants and inclusion ratios of six inclusion complexes were determined , The influence of electron pushing group and electron absorbing group on the inclusion process is discussed , The results show that the electron pushing groups are more favorable for the formation of inclusion complexes . A new type of porphyrin has been designed and synthesized 5-（4- Benzoimide phenyl ）-10,15,20- Triphenyl porphyrin （BATPPH2） And its Zn Complexes （BATPPZn）, The compounds were characterized in detail and their structures were confirmed . Using fluorescence spectrometry 、 Ultraviolet — Visible spectrophotometry and 1H NMR Technology studies BATPPH2 as well as BATPPZn Supramolecular systems formed with cyclodextrins of different cavity sizes . The results show that BATPPH2 and BATPPZn Size 、 Geometry and γ-CD The size and properties of the cavity are more matched ;Zn2+ The stability of the inclusion complex is reduced by the coordination of the , However, the inclusion ratio of inclusion complex is not greatly affected . A series of amino porphyrins with different substitution positions and different numbers of functional groups were synthesized :5-（4- Aminophenyl ）-10,15,20- Triphenyl porphyrin （ATPPH2）、5,10- Two （4- Aminophenyl ）-15,20- Diphenylporphyrin （Cis-DADPPH2）、5,15- Two （4- Aminophenyl ）-10,20- Diphenylporphyrin （Trans-DADPPH2）、5- phenyl -10,15,20- 3、 ... and （4- Aminophenyl ） porphyrin （Tri-APPH2） And four （4- Aminophenyl ） porphyrin （TAPPH2）, The compounds were characterized in detail and their structures were confirmed . The interaction between cyclodextrin and it was studied （α-CD、β-CD and γ-CD） Supramolecular systems , The effects of different numbers and positions of amino functional groups on inclusion were discussed . The results showed that Diaminophenyl substituted porphyrins were para substituted （5, 15 position ） To replace with a neighbor （5, 10 position ） More conducive to α-CD、β-CD and γ-CD To form stability 、 A single inclusion ; The number of amino functional groups has a certain influence on the inclusion process , The increase of its number is beneficial to the stability of the inclusion process 、 Proceed in an orderly manner . The correlation coefficients of all inclusion complexes are determined , The law and mechanism of the action were investigated , Contact the life science to find the possibility of its application . The study of this series of supramolecular systems is systematic , In seriality 、 Looking for rules in systematic research , Strong theoretical significance .

 

5,10- Two (4- Aminophenyl )-15,20- Diphenylporphyrin (Cis-DADPPH2)

5,15- Two (4- Aminophenyl )-10,20- Diphenylporphyrin (Trans-DADPPH2)

5- phenyl -10,15,20- 3、 ... and (4- Aminophenyl ) porphyrin (Tri-APPH2)

Octaethyl porphyrin cobalt (OEPCo)
4,4',4'',4'''- Cobalt tetraformamide phthalocyanine (Co-tamPc)
Cobalt formamide phthalocyanine (P-tamPcPo)
4,4',4'',4'''- Cobalt tetracarboxyphthalocyanine (Co-taPc)
4,4',4'',4'''- Tetraphenylalanine ethyl ester cobalt phthalocyanine (phe-PcCo see P20)
4,4',4'',4'''- Tetrahydroxy tetraphenyl porphyrin (4OH-TPP)
Median -[ adjacent -(3- Mercaptobenzamide group ) phenyl ) Triphenylporphyrin manganese (Ⅲ)( abbreviation Mn(Ⅱ)(m3phsH)
Monosubstituted acid tetraphenyl porphyrin zinc complex Zn「Val-TPP」,Zn「Glu-TPP」,Zn「Tyr-TPP」 and Zn「Trp-TPP」
5-(4- Glycine butoxyphenyl )-10,15,20- Triphenyl porphyrin (H2P)
Metal tetraphenyl porphyrin [Co(II)TPP,Fe(III)TPPCI,Mn(III)TPPCI,Zn(II)TPP,Cu(II)TPP
P-methoxytetraphenyl iron porphyrin chloride (TMPPFeCl)
β- Unsubstituted tetraphenylporphyrin (TPP):β-Cl8TPP、β-Br8TPP、β-Br4TPP、β-NO2TPP、β-(CH3)8TPP
5,10,15,20-(2,6- Dichlorophenyl )- Porphyrin manganese complex Mn(TDCPP)Cl
5,10,15,20-(2,6- Dichlorophenyl )- Porphyrin ruthenium complex Ru(TDCPP)CO]
5- O-HYDROXYPHENYL -10,15,20- Triphenyl porphyrin (TPPOH)
5- O-HYDROXYPHENYL -10,15,20- 3、 ... and ( P-methoxy ) Phenylporphyrin [(p-OCH3)TPPOH] compound
β- Nitrotetraphenyl porphyrin [H2 TPP(NO2)]
β- Nitrotetraphenyl porphyrin zinc complex [ZnTPP( NO2 )]
2,3,7,8,12,13,17,18- Octafluoro -5,10,15,20- Four ( Pentafluorophenyl ) porphyrin (F28TPPH2)

This article comes from Xiaobian axc.2022.02.14