Cholesterol-PEG-NHS NHS-PEG-CLS cholesterol-polyethylene glycol-active ester can modify small molecular materials

I. Details

1. Name

Chinese: cholesterol-polyethylene glycol-active ester (MW: 3400)

English: Cholesterol-PEG-NHS

NHS-PEG-CLS

2. Properties

Molecular weight: 3.4k, other molecular weights can be customized (5k, 2k, 1k, etc.).Quality control at 95%+.

Physical Properties: Solid or liquid depending on molecular weight.Soluble in conventional solutions and most organic solvents.

Storage conditions: Freeze at -20°.Store away from light and dry.

Uses: For scientific research, drug release, nanotechnology and new material research, cell culture.Active compounds in the research of ligands, peptide synthesis supports, grafted polymer compounds, new materials and polyethylene glycol modified functional coatings.

Reminder: In order to achieve the best use effect, the material should always be kept in a dry low temperature condition.Avoid frequent thawing and freezing.

Second, structural formula

Three, description

Active esters react with primary amine groups at pH 7-8.5 to form stable amide bonds.Polyethylene glycol increases solubility and stability, reduces the originality of polypeptides and proteins, and inhibits non-specific binding of charged molecules on modified surfaces.Proteins, polypeptides and other small molecule materials can be modified.It is used in medical research, sustained release of medicinal properties, research on new nanomaterials, and cell culture.It has become a research trend in the research of ligands of active compounds, peptide synthesis carriers, macromolecular graft compounds, polyethylene glycol coatings and modification and functionalization of materials.

CLS - PEG - the NHS is a kind of different double functional group PEG derivatives, cholesterol is forms the foundation of liposome membrane and material, is an indispensable important material of animal tissue cells, which not only participate in the formation of thecell.Film, and is a synthesis of bile acid, vitamin D and leave the body to produce raw materials. Cholesterol can adjust the liquidity of phospholipid bilayer membrane, reduce the membrane permeability, reduce drug leakage. At the same time maintain a certain flexibility,can make the lipid membrane enhanced liposome vesicle in the fight against external conditions change. And for the oxidation of phospholipids have certain protective effect. Active ester (NHS) PH7 8.5 react with primary amine groups to form stable amide bond. Through PEG connection of cholesterolhas better solubility in water, PEG cholesterol derivatives can be used in the membrane imaging, liposomes, and drugs transmission.

Four, related products

Cholesterol-PEG-active ester, Cholesterol-PEG-NHS, NHS-PEG-CLS, MW: 20000

Cholesterol-polyethylene glycol-active ester, Cholesterol-PEG-NHS, NHS-PEG-CLS, MW: 10000

Cholesterol-PEG-active ester, Cholesterol-PEG-NHS, NHS-PEG-CLS, MW: 5000

Cholesterol-PEG-active ester, Cholesterol-PEG-NHS, NHS-PEG-CLS, MW: 3400

Cholesterol-PEG-active ester, Cholesterol-PEG-NHS, NHS-PEG-CLS, MW: 1000

Cholesterol-PEG-Amino, Cholesterol-PEG-Amine, CLS-PEG-NH2, MW: 20000

Cholesterol-PEG-Amino, Cholesterol-PEG-Amine, CLS-PEG-NH2, MW: 10000

Cholesterol-PEG-Amino, Cholesterol-PEG-Amine, CLS-PEG-NH2, MW: 5000

Cholesterol-PEG-Amino, Cholesterol-PEG-Amine, CLS-PEG-NH2, MW: 3400

Cholesterol-PEG-Amine, Cholesterol-PEG-Amine, CLS-PEG-NH2, MW: 1000