Chinese and English instructions human soluble advanced glycation end products receptor (sRAGE) ELISA Kit

The receptor for advanced glycation end products (RAGE) is a multiligand member of the immunoglobulin superfamily of cell surface molecules. It mediates interactions of advanced glycation end products (AGE), the products of nonenzymatic glycoxidation of proteins/lipids that accumulate in the plasma and tissues of patients with diabetes.

Soluble Receptor for Advanced Glycation End Products (sRAGE) Human ELISA：

RD191116200R 96 wells (1 kit)

Regulatory status:RUO

Type:Sandwich ELISA, Biotin-labelled antibody

Other names:Soluble Receptor for Advanced Glycation End Products, sRAGE, Advanced glycation end product-specific receptor, AGER, RAGE

Species:Human

Type:Sandwich ELISA, Biotin-labelled antibody

Applications:Serum, Plasma

Sample Requirements:50 μl/well

Shipping:At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration:Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Range:50–3200 pg/ml

Limit of Detection:19.2 pg/ml

Intra-assay (Within-Run):n = 8; CV = 4.0%

Inter-assay (Run-to-Run):n = 6; CV = 7.2%

Spiking Recovery:94,00%

Dilution Linearity:101,60%

sRAGE: soluble RAGE,  Soluble RAGE：

Except for the full length RAGE Outside , There are also two types of shears , One is N End shear body , Function unknown ; One is C End shear body , Lack of transmembrane region , Secreted in plasma , In soluble form , Also called esRAGE (endogenous secretory RAGE).sRAGE Able to combine AGEs Isoligand , Prevent it from contacting the full length of the membrane RAGE combination , So as to block the vascular damage caused by its signal transduction pathway , At the same time, it helps AGEs And so on . therefore sRAGE It can protect blood vessels , It can adjust in a negative direction AGEs Receptor dependent pathogenesis . in vivo RAGE There are individual differences in the level of shear body , This makes patients with diabetes have different susceptibility to vascular disease .   

Clinically ,sRAGE Decreased levels are markers of loss or imbalance of inflammatory control , Related to cardiovascular disease . In patients with hypertension ,sRAGE Levels are negatively correlated with blood pressure . And in the serum of patients with end-stage renal disease and acute lung injury ,sRAGE The level rises obviously .

AI Meijie  BioVendor sRAGE Elisa Chemical properties of the kit ：

full name ： Advanced glycation end products  (sRAGE)  people  ELISA  Soluble receptor of

type ： Sandwich  ELISA, Biotin labeled antibody

Other names ： Soluble receptors for advanced glycation end products ,sRAGE, Advanced glycation end products specific receptors ,AGER,RAGE

species ： human beings

application ： serum 、 The plasma

Sample requirements ：50 Microlitre / hole

Storage / expire ： Store the complete kit in  2–8°C. under such conditions , The kit is stable before the expiration date （ See the label on the box ）.

AI Meijie  BioVendor sRAGE Elisa Kit features ：

It is for research purposes only .

The total determination time is less than  3.5  Hours .

The kit measures serum and plasma （EDTA、 Citrate 、 heparin ） Medium  sRAGE.

The measurement format is  96  hole .

The standard is based on recombinant proteins

Quality control is based on human serum . Do not use animal serum .

The components of the kit can be used directly 、 Concentrated or lyophilized .