MOFs, metal organic framework materials of folic acid ligands, are loaded with small molecule drugs such as 5-fluorouracil, sidabelamine, taxol, doxorubicin, daunorubicin, ibuprofen, camptothecin, cur

Metal organic framework material of folic acid ligand MOFs load 5- Fluorouracil , Sidabelamine , Paclitaxel , Adriamycin , Daunorubicin , Ibuprofen , Camptothecin , Curcumin , Small molecule drugs such as gambogic acid

Metal — Organic skeleton （MOFs） Materials represent a class of heterozygous organic compounds — Inorganic supramolecular materials , It's through Organic bridging ligands combine with inorganic metal ions to form an ordered network structure .MOFs Present the highest Specific surface area , Minimum crystal density and adjustable pore size and functional structure , send MOFs Can achieve some special Special application , Including gas storage and separation , Catalysis and drug release . By introducing functions into organic ligands Group or utilize MOFs The active component is introduced as the host environment , Synthesize functionalized MOFs material , It can be big Broaden the scope of its application

We use MOFs Folic acid was selected as the organic ligand , Make it have tumor cell targeting . also MOFs The material has drug loading capacity , Loadable 5- Fluorouracil , Sidabelamine , Paclitaxel , Adriamycin , Daunorubicin and other drugs . When folate receptors in tumor cells bind to folate ,MOFs The skeleton of the material is damaged , So that the drug loaded in it is released .

 

[email protected]@[email protected]@M

[email protected] Loaded adriamycin hydrochloride (DOX)

Glycyrrhetinic acid modified metal organic framework materials UiO-66-NH2（UiO-66- NH2-GA）

UiO-66 Encapsulated bendamostine

UiO-66-NH2 Encapsulated bendamostine

UiO-66-COOH Encapsulated bendamostine

Metal organic frame material UiO66COOH Package load 5-Fu(5- Fluorouracil )

Metal organic frame material UiO66NH Package load 5-Fu(5- Fluorouracil )

Metal organic frame material UiO-66 Encapsulated ciprofloxacin hydrochloride (CIP)

[email protected]@WP6 Drug loading material

UiO-66 Loading ciprofloxacin hydrochloride

UiO-66(Ce) load 5-Fu(5- Fluorouracil )

The above information comes from Xiaobian axc,2022.06.10