Uio-66-cooh loaded bendamostine | hydroxyapatite (HA) coated MIL-53 (FE) nanoparticles | baicalin loaded manganese based metal organic skeleton material

UiO-66-COOH Load bendamostine ; hydroxyapatite ( HA) The parcel MIL-53(Fe) Nanoparticles ;| Baicalin loaded manganese based metal organic framework material ;

MOFs Having a unique nature , Such as highly ordered structure 、 High specific surface area and large pore volume , It can adsorb functional molecules on its outer surface or open channels , And trap these molecules in the skeleton . Besides , Functional molecules can be synthesized by one pot method or modified after synthesis , Bound to by covalent bonds MOFs in . There are mainly four advanced strategies to make MOFs Functionalization , Include ： Surface adsorption 、 Hole encapsulation 、 Covalent binding and functional molecules as building blocks .

UiO-66-COOH Introduction of loading bendamostine

With metal Zr Ion centered , Three metal organic frameworks were synthesized with different organic ligands (MOFs) carrier (UiO-66,UiO-66-NH2,UiO-66-COOH), And loading bendamostine by impregnation , Three MOFs The vectors were successfully loaded with bendamostine , And three MOFs The crystal structure of the carrier does not change before and after drug loading , Strong thermal stability , among UiO-66-COOH The drug loading capacity of is better than UiO-66-NH2 and UiO-66.

 

Metal organic frameworks MOF-5 Loading triamterene （[email protected]）

MOF-808 Metal organic skeleton loading 5-Fu(5- Fluorouracil )

CD-MOF Cyclodextrin - Methotrexate is encapsulated in metal organic framework

MOF-199 Loading adriamycin (DOX)

Metal organic frameworks MOF-53 Loading taxol

MOF-5 Containing ibuprofen

Eu-MOF Camptothecin loaded

Terbium based metal organic framework material Tb-MOF Loading curcumin

Dysprosium based metal organic framework material Dy-MOF It contains gambogic acid

Pd-MOF Loaded carbenicillin

Bio-MOF-11 load MTX Methotrexate

The above information comes from Xiaobian axc,2022.06.15