Cross linked cyclodextrin metal organic framework loaded methotrexate slow-release particles | metal organic porous material uio-66 loaded with flavonoid glycosides | Qiyue

Cross linked cyclodextrin metal organic framework loaded methotrexate sustained-release particles | Metal - Organic porous materials UiO-66 Loaded flavonoid glycosides | Qi Yue

It has stable physicochemical properties 、 A porous metal with a large specific surface area - Organic framing materials UiO-66 As a carrier , Mangiferin is the target for loading flavonoid glycosides , The drug loading and release behavior of the carrier to mangiferin . Through powder X X-ray diffraction (PXRD) It was determined that the porous framework remained unchanged before and after drug loading and drug release ; Adsorbed mangiferin UiO-66 Fourier transform of solid samples (FT-IR) The infrared spectrum shows the presence of tertiary carbon (C-H)、 Aromatic ketones (CO)、 Aromatic ether (C-O-C), Fatty ether (C-O-C) Stretching vibration peak , It is proved that mangiferin exists in the porous framework . Using UV - Drug loading and release were tracked by visible spectrophotometry . Experimental results show that : stay Tris-HCl Porous material in buffer solution UiO-66 The drug loading capacity can reach 0.314g/g, The load rate reaches 67％. The drug is released for as long as 144h, It has long-term release performance . The porous material UiO-66 The amount of drugs loaded is considerable , It has a high potential application prospect .

CCOF-1 load MTX Methotrexate

Covalent organic framework materials COF-5 Paclitaxel encapsulated PTX

COF-105 Loading adriamycin DOX

COF-102 Loading cisplatin CDDP

Covalent organic framework materials COF-300 Package load CPT Camptothecin

CCOF-1 Loading ciprofloxacin

COF-5 Loading metronidazole

COF-105 Loaded with letitrexed

Covalent organic framework materials COF-102 Load pemetrexed

The above information comes from Xiaobian axc,2022.06.15