Metal organic framework (MOFs) antitumor drug carrier | pcn-223 loaded with metronidazole | uio-66 loaded with ciprofloxacin hydrochloride（ 2022-07-03 13:57:00 【qiyueshengwu】 Metal organic frameworks (MOFs) Antineoplastic drug carrier ;PCN-223 Loading metronidazole ;UiO-66 Encapsulated ciprofloxacin hydrochloride ([email protected]) Usually , The drug is loaded into... By in situ encapsulation or post synthesis modification strategy MOFs in . The former is a relatively simple method , It is suitable for heat stable drugs to overcome the premature release of drugs . The latter provides a more benign environment to avoid damaging drug molecules . With MOF Development of Chemistry , Has explored a series of MOFs As a promising candidate carrier in this field .UiO-66 Encapsulated ciprofloxacin hydrochloride ([email protected]) Introduction to Metal organic frame material UiO-66 Ciprofloxacin hydrochloride as carrier (ciprofloxacinhydrochloride,CIP) Loading , Prepared in one pot [email protected] It has regular octahedral structure and stable crystal structure , Use one pot method to load CIP The drug loading rate is higher than that of impregnation , With UiO-66 Load the carrier CIP Can effectively improve CIP Antibacterial effect of . The conclusion is UiO-66 As a good drug carrier, it provides a strong basis .UiO-66 The pore structure of consists of 1.1nm The left and right regular octahedral cages are connected with 0.8nm The left and right tetrahedral cages pass 0.6nm The triangular windows of are connected ( See the picture 1). although UiO-66 The ideal ligand coordination number of is 12, However, there are some ligand defects in its actual structure , This ligand defect lies in other MOFs Not often .UiO-66 The degree of ligand defects in the structure directly affects its specific surface area , Ligand defects can be determined by synthetic conditions ( Such as crystallization time or temperature ) And add different kinds of regulators to regulate , therefore ,UiO-66 The specific surface area of is generally 600~1600m2/g Within the scope of . Zn-MOF Loading adriamycin DOXMOF-5 Loaded with capsaicin ( capsaicin)Zn-MOF Loaded cisplatin Cyclodextrin - Metal organic frameworks (CD-MOF) Load baixiaoan copper - Metal - Organic framework nanoparticles (Cu-MOF NPs) Loading the sound sensitive agent dihydroporphyrin (Ce6)MOF Bacteriostatic membrane loaded with procyanidins MOFs Nanoparticles modified deoxyribonucleic acid (DNA)MOFs Nanoparticles modify RNA (RNA) Adriamycin drug carrier La/[email protected] compound material Metal organic frameworks MOF-5 Loading triamterene （[email protected]）MOF-808 Metal organic skeleton loading 5-Fu(5- Fluorouracil ) The above information comes from Xiaobian axc,2022.06.15

Metal organic frameworks (MOFs) Antineoplastic drug carrier ;PCN-223 Loading metronidazole ;UiO-66 Encapsulated ciprofloxacin hydrochloride ([email protected])

Usually , The drug is loaded into... By in situ encapsulation or post synthesis modification strategy MOFs in . The former is a relatively simple method , It is suitable for heat stable drugs to overcome the premature release of drugs . The latter provides a more benign environment to avoid damaging drug molecules . With MOF Development of Chemistry , Has explored a series of MOFs As a promising candidate carrier in this field .

UiO-66 Encapsulated ciprofloxacin hydrochloride ([email protected]) Introduction to

Metal organic frame material UiO-66 Ciprofloxacin hydrochloride as carrier (ciprofloxacinhydrochloride,CIP) Loading , Prepared in one pot [email protected] It has regular octahedral structure and stable crystal structure , Use one pot method to load CIP The drug loading rate is higher than that of impregnation , With UiO-66 Load the carrier CIP Can effectively improve CIP Antibacterial effect of . The conclusion is UiO-66 As a good drug carrier, it provides a strong basis .

UiO-66 The pore structure of consists of 1.1nm The left and right regular octahedral cages are connected with 0.8nm The left and right tetrahedral cages pass 0.6nm The triangular windows of are connected ( See the picture 1). although UiO-66 The ideal ligand coordination number of is 12, However, there are some ligand defects in its actual structure , This ligand defect lies in other MOFs Not often .UiO-66 The degree of ligand defects in the structure directly affects its specific surface area , Ligand defects can be determined by synthetic conditions ( Such as crystallization time or temperature ) And add different kinds of regulators to regulate , therefore ,UiO-66 The specific surface area of is generally 600~1600m2/g Within the scope of .

 

Zn-MOF Loading adriamycin DOX

MOF-5 Loaded with capsaicin ( capsaicin)

Zn-MOF Loaded cisplatin

Cyclodextrin - Metal organic frameworks (CD-MOF) Load baixiaoan

copper - Metal - Organic framework nanoparticles (Cu-MOF NPs) Loading the sound sensitive agent dihydroporphyrin (Ce6)

MOF Bacteriostatic membrane loaded with procyanidins

MOFs Nanoparticles modified deoxyribonucleic acid (DNA)

MOFs Nanoparticles modify RNA (RNA)

Adriamycin drug carrier La/[email protected] compound material

Metal organic frameworks MOF-5 Loading triamterene （[email protected]）

MOF-808 Metal organic skeleton loading 5-Fu(5- Fluorouracil )

The above information comes from Xiaobian axc,2022.06.15