Formation of mil-100 (FE) coated small molecule aspirin [email protected] (FE) | glycyrrhetinic acid modified metal organ

MIL-100( Fe) Wrapping small molecules of aspirin to form [email protected](Fe）| Glycyrrhetinic acid modified metal organic framework materials UiO-66-NH2（ abbreviation UiO-66-NH2-GA）

Drug carrier means that it can change the way drugs enter the human body and the distribution in the body 、 A system that controls the rate of drug release and delivers drugs to targeted organs . The conditions that a drug carrier should have :(1) Have a - Quantitative drug carrying capacity ;(2) Release the drug after reaching the target site ;.(3) It has - The dispersity and stability of the determination ;(4) It has certain biocompatibility with tissues and cells , And no toxicity . The targeting of drugs can be divided into 3 level : The first 1 Grade refers to reaching a specific target tissue or organ ; The first 2 Level refers to reaching a specific cell ; The first 3 Level refers to reaching a specific part of the cell .3 Level targeting enables drugs to function at the cellular level , Selectively attack diseased cells , It has no or almost no adverse effects on normal cells , So as to achieve the desired curative effect .

Glycyrrhetinic acid modified metal organic framework materials UiO-66-NH2（ abbreviation UiO-66-NH2-GA） Introduction to

Metal organic framework (Metalorganicframeworks,MOFs) It is a new type of ductile network organic material formed by organic bridging ligands connecting inorganic metal ions or ion clusters with organic ligands through coordination bonds ,MOFs The structural diagram of is as shown in the figure 1 Shown . because MOFs With super high specific surface area 、 Adjustable aperture 、 The crystal structure is easy to modify 、 Easy chemical functionalization 、 Biodegradability and good biocompatibility , Therefore, it can be used as a good drug carrier .UiO-66-NH2 Is made of metal ions Zr It has a porous octahedral structure combined with aminoterephthalic acid through coordination MOFs material , High thermal stability , It can effectively prevent structural collapse , In water 、N,N- Dimethylformamide 、 acetone 、 The crystal structure stability can be maintained in benzene and other solvents , It also has strong alkali resistance and certain acid resistance .

 

MOF-74 Paclitaxel encapsulated PTX

MOF-199 Loading adriamycin DOX

Metal organic frameworks MOF-303 Loading cisplatin CDDP

MOF-808 Package load CPT Camptothecin

CD-MOF Loading ciprofloxacin

Metal organic frameworks MOF-5 Loading metronidazole

Eu-MOF Loaded with letitrexed

Metal organic frameworks MOF-199 Load pemetrexed

MOF-303 Loading anisamide

Tb-MOF Package load Ad Adamantane

Dy-MOF Azithromycin loaded

The above information comes from Xiaobian axc,2022.06.15