Abbexa 8-OHdG CLIA kit solution

8-Oxo-2'-deoxyguanosine (8-oxo-dG)  It is an oxidative derivative of deoxyguanosine .8-Oxo-dG  yes  DNA  One of the main products of oxidation . Intracellular  8-oxo-dG  Is a measure of oxidative stress .

AI Meijie  Abbexa 8-Hydroxydeoxyguanosine (8-OHdG) CLIA Kit  Is a competitive  CLIA  Kit , Applicable to serum 、 Plasma and other biological fluids .

AI Meijie Abbexa 8-OHdG CLIA  Kit parameters ：

The goal is  8-Hydroxy-2' - Deoxyguanosine  (8-OHdG)

Reactivity   commonly （ All species ）

The test application  CLIA

Recommended dilution   Precise dilution / The concentration shall be determined by the user .

Keep in storage   stay  4 °C  Lower transportation . Or store the kit according to the storage instructions .

effectiveness  6  Months .

Stable   The stability of the kit depends on the activity loss rate . Under proper storage conditions , The loss rate within the warranty period is less than 5%. To minimize performance fluctuations , Operating procedures and laboratory conditions should be strictly controlled . It is also strongly recommended that the entire determination be performed by the same user from beginning to end .

Test range  23.44  Gerard pique / ml  - 6000  Gerard pique / ml

sensitivity  < 10.86  Gerard pique / ml

A standard format   Freeze drying

test method   Chemiluminescence

Detection type   Competitive

Test data   Quantitative

Sample type   serum 、 Plasma and other biological fluids .

For research purposes only .

standard      6000  Gerard pique / ml

AI Meijie Abbexa8-OHdG CLIA  Kit related articles ：

1、8- hydroxyl -2'- Deoxyguanosine （8-OHdG ）： Key biomarkers of oxidative stress and carcinogenesis .

Valavanidis A、Vlachogianni T、Fiotakis C.

J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009  year  4  month ;27(2):120-39.doi：10.1080/10590500902885684.

PMID: 19412858

A great deal of experimental evidence shows that , Oxidative damage occurs permanently on the cell membrane 、 Protein and  DNA  On the lipid of .

2、8 -Oxo-7、8 -Dihydro- 2'- Deoxyguanosine ( 8 -oxodG ) and 8 - Hydroxy - 2'- Deoxyguanosine ( 8 - OHdG ) As gestational diabetes  (GDM)  Potential biomarkers for development matter .

Urbaniak SK、Boguszewska K、Szewczuk M、Kaźmierczak-Barańska J、Karwowski BT.

molecular .2020  year  1  month  3  Japan ;25(1):202.doi：10.3390/ molecular 25010202.

 

PMID: 31947819

Guanine is the most sensitive nucleobase to oxidative stress . Its damage leads to two main modifications ：8- hydroxyl -2'- Deoxyguanosine or 8- Oxygenation -7、8- Dihydrogen -2'- Deoxyguanosine .