PNA peptide nucleic acid modified peptide suc Tyr Leu Val PNA | suc ala Pro Phe PNA 11

PNA Peptide nucleic acid modifies polypeptide Suc-Tyr-Leu-Val-pNA|Suc-Ala-Pro-Phe-pNA 11

PNA characteristic

Strong binding force ：PNA It is composed of electrically neutral amide skeleton , therefore PNA Chain and DNA There is no repulsion between chains , therefore ,PNA And DNA Have stronger binding force between .

Strong specificity and sensitivity ： In the absence of mismatches ,PNA/DNA The combination stability is stronger than DNA/DNA; In case of mismatch ,PNA/DNA The binding stability is weaker than DNA/DNA. Even a single base mismatch , It will also cause great differences in the dissolution curve . therefore , It can distinguish the mismatch of a single base . Didn't show up 1 A mismatch of bases ,Tm The average value decreases 15°C, If 2 Base mismatch , You can't cross at all , Therefore, the specificity is high .

Strong stability ：PNA Strong chemical , biology , Thermodynamic stability .PNA In the heat , strong PH Under the condition of , Both have strong stability . And because of PNA Skeletons are different from nucleic acid and polypeptide skeletons , therefore , Nuclease and protease are not easy to degrade PNA.

Strong hybridization stability ：PNA It has strong stability in the hybrid solution with high salt concentration , And cohesion . therefore ,PNA It can be used as a relatively stable hybridization probe in scientific research . Under the same conditions ,15 Bases with the same sequence ,DNA/DNA Of Tm The value is 53.3°C,DNA/RNA Of Tm The value is 50.6°C,PNA/DNA Of Tm Value up to 69.5°C,PNA/PNA More than that 72.3°C, That is, compared with the nucleic acid base sequence of the same sequence , Every increase 1 Base , Increase of chain breaking temperature 1°C, Improved hybridization stability .

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