Only 38 years old! Zhou Chuan, a researcher of the Chinese Academy of Sciences, died unfortunately. Rao Yi sent a document to mourn: he guided me when he was still my student

According to Rao Yi science official account , Raoyi's former student 、 Zhou Chuan, researcher of Institute of zoology, Chinese Academy of Sciences 2 month 10 He passed away on April 15 , Years old 38 year ！

2 month 20 Japan , Rao Yi Send a eulogy on his personal official account 《 Mourn for Zhou Zhuan ： Students who have instructed teachers 》 Mourn for Zhou Zhuan , call ：“ Zhou Although Chuan was once my graduate student , But he instructed me at that time ”.

It is reported that , Researcher Zhou Chuan from 2015 Work after returning to China in , A series of research achievements have been made in the research field , once Selected into the new 100 Talents Program of the Chinese Academy of Sciences ,2016 In, he was supported by the National Excellent Youth Fund .

However , When his career is sailing , Zhou Chuan was diagnosed with illness .

Because the prognosis of the disease is poor 、 Great side effects , Zhou Chuan decided not to treat , In order to have more “ health ” Time for .

During illness , He insisted on scientific research . After blindness , Have to go through 17 Hours of surgery . But he continued to direct the research in the laboratory , Communicate with students , Until it is completely impossible . Sometimes a wife and mother are required to record . After his serious illness , He led the laboratory to publish an original research paper （Wu et al., 2020）、 The student received a doctorate . Zhou Chuan's lab has two more articles in the process of submission （Wang et al.; Ma et al.）.

Professor raoyi said ： Zhou Chuan is from Peking University 、 Tsinghua can be proud of its ideals 、 An emotional student . They foreshadow the hope that our country will have successors in the future .

Zhou Zhuan , male , Doctor , researcher , Doctoral supervisor ; Head of insect behavior and neuromodulation research group, Institute of zoology, Chinese Academy of Sciences .

2005 He received his bachelor's degree from the Department of biology of Tsinghua University in .2005－2010 He studied for a doctorate at the Beijing Institute of life sciences .2011-2015 He conducted postdoctoral research at the Jennings research campus of Howard Hughes Medical Research Institute .

since 2005 Since, we have been studying the neural mechanism of social behavior using Drosophila as a model , It mainly focuses on the molecular and neural mechanisms of fighting and lovelorn behavior in Drosophila , Pheromone and neural circuit mechanism of courtship song perception in Drosophila courtship behavior . The applicant is the first author in Neuron、Nature Neuroscience、Journal of Neuroscience And other famous journals . By many scientific journals such as Nature、Nature Neuroscience、Neuron、Nature Reviews Neuroscience And many other media, such as Science News、The Scientist、The Verge、redOrbit And so on . Won the first wurui award and NIBS Excellent graduate award .

research field ：

（1） Drosophila melanogaster was used as a model to study the neural circuit and sensory information flow transmission mechanism related to fighting and courtship behavior .

（2） The neural mechanism of mating behavior and blood sucking behavior of Aedes aegypti was studied .
（3） Study the true social behavior of ants , Especially the neural mechanism of social division of labor and cooperation .

Rao Yi The full text of the eulogy is as follows ：

Mourn for Zhou Zhuan ： Students who have instructed teachers

Rao Yi

Although Zhou Chuan was once my graduate student , But he instructed me at that time .

Zhou Chuan, researcher of Institute of zoology, Chinese Academy of Sciences （1984 year 3 month 3 solstice 2022 year 2 month 10 Japan ） Unfortunately, he died of illness .

2003 year , I'm in charge of the graduate course in biology （BIO2000） From Shanghai Institute of life sciences, Chinese Academy of Sciences to Peking University 、 tsinghua . I'll give my first lesson , A small number of undergraduate students from Peking University and Tsinghua University also attend .

Zhou Chuan, a junior at Tsinghua University, and Wang Liming, a fellow at Peking University, not only came to attend classes , Then I began to contact , Discuss science .

My first suggestion to Zhou Chuan is , To Institute of Biophysics, Chinese Academy of Sciences , Learn from xutao TIRF technology . Wang Liming is arranged to go to Shanghai to meet with Jiang Hui, a graduate student .

When Liming returned to Beijing , I suggest that Zhou Chuan and liming test whether fruit flies are sensitive to magnetic fields . I arranged for them to learn behavior experiments with fruit flies from tangshiming, who was still in the Institute of Biophysics at that time .

Do animals have magnetic induction , It is a long-term controversial scientific issue . My idea is , If the fruit fly has magnetic induction , Genetic methods can be used to screen related genes , Find out the mechanism of magnetic induction , Later, magnetic induction molecules may be developed to regulate the activity of nerve cells （ Now it can be called “ Magnetogenetics ”）. Before , Foreign countries have studied the magnetic induction of Drosophila , But few 、 No consensus . Zhou Chuan and liming struggled in Biophysics for some time , There is no definite conclusion .

Zhou Chuan is in the Rao Laboratory of Beisheng Institute

2005 After graduating from Tsinghua University in , Zhou Chuan was admitted by the Institute of Biophysics and joined the laboratory I established at the Beijing Institute of life sciences . The laboratory of Beisheng Institute was founded at that time . I have been a graduate student for five of my six years （1986-1991） I have done research on fruit flies , But to 2005 I haven't been a fruit fly for a long time , And I never set up a lab for fruit flies . I asked Professor raoyong from Canada （ Non relatives ） Help , And the country relies on new students . Zhou Chuan and liming played a great role in establishing the fruit fly laboratory . And wanglupeng, a student of China Agricultural University .

I suggest the three of them study whether they can induce Drosophila to produce depression . The incidence rate of depression is very high , The mechanism is not clear , The effect of drug treatment is limited . If you can build a depression model with fruit flies , Then we can use the powerful genetic and molecular biological means of Drosophila , Explore the molecular mechanism of depression , It even led to the development of new drugs for the treatment of depression . The three of them started with what depression is , The concept and experiment are discussed , They designed some behavioral paradigms , Some drugs and genetic mutation manipulation have also been done . however , The Drosophila depression model we explored , Does it count , We are not confident 、 No conclusion .

In the process , Zhou Chuan decided to use fruit flies for social behavior ： fight . He read the literature first himself , Offer to fight , Then discuss with me the significance of this research field , Questions to answer , And experimental methods . I was persuaded by him to .

My lab has done research on fruit fly fighting , It was founded by Zhou Chuan . 

I wrote in every letter of recommendation to him ：

The molecular mechanism of social behavior was one of the research contents in my laboratory for nearly ten years , Zhou Chuan's idea is the starting point of these studies . and , The research on the mechanism of social behavior has been the main research field of my laboratory for several years . therefore , Zhou Zhuan is a guide to me , It drives the whole laboratory .

To be arrogant , We sometimes call ourselves research “ Molecular sociology ”.

Zhou Zhuan （2008） The first paper was published in Nature Neuroscience, Only three authors , The last two of Zhou Chuan are teachers , So all the experiments were done by Zhou Chuanyi . Zhou Chuan found , Amines are important in fighting fruit flies , He manipulated genetic mutations through molecular biology , It was found that lowering the neurotransmitter amines in Drosophila melanogaster can reduce fighting , Adding amines can increase fighting . Through genetic manipulation , He determined that amines in five neurons were important for fighting .

There are several authors in Zhou Chuan's second paper , But the latter are only Drosophila strains that provide genetic mutations , So he did all the experiments by himself . He discovered the molecular mechanism of how male fruit flies adapt to rejection of courtship . He discovered amines and one of their receptors （OAMB） It is very important to adapt to the rejection of courtship . If these molecules decrease , Male flies do not stop courting after being rejected , Continue to pursue female flies tirelessly （ Zhou Chuan et al ,J Neurosci,2012）.

  In addition to these two original papers , Zhou Chuan also published a comment with him as the corresponding author .

2008 year , Zhou Chuan exchanged his research work at the Institute of genetic development, Chinese Academy of Sciences

He also has a very interesting article , Has not been published . He studied the effects of alcohol on fighting behavior in fruit flies . He quoted “ wine is glowing in the luminous jade cups ” Start .

Zhou Chuan took part in the spare time activities of the summer school in Kunming

obviously , Scientific research for Zhou Chuan , Both meaningful , Also a lot of fun .

In my letter of recommendation to him ： Without a mentor , Only highly independent 、 Especially creative 、 Only self disciplined students can succeed … Students like Zhou Chuan , It has strengthened my confidence to return home full-time .

Zhou Chuan also likes teaching .2009 year , Zhang Yi 、 Zhou Zhuan 、 Student libingfeng once opened in my name “ Genes and behavior ” Curriculum . They make the course more difficult , Students are required to read five original research papers in English every week , And write one or two pages of commentary for each paper . Scared a large number of undergraduate and graduate students , By the way, my reputation has been very cruel among the undergraduates of Peking University Graduate School of biological sciences . An undergraduate took this course in Peking University , Later in the United States, the students who received their doctoral degrees as graduate students recalled ：

 “ I took this course . Students were required to read five original research papers a week .  The difficulty is to write oneortwo pages of comments for each article . by comparison , When I choose a similar graduate course in the United States, I need to write a comment on any one of the five articles . This is the most burdensome class I have ever chosen , At that time, I spent half of my spare time every week writing the homework for this course , Of course, this course also systematically trained my method of reading research papers . At that time, there were less than students in Peking University 5 The rule that people cannot start classes , In the second week, because there were so few people, I almost couldn't open classes .

Later, when I was a graduate student and began to be a teaching assistant, I remembered , I think Zhou Chuan was a graduate student at that time （ Zhang Yi is an undergraduate ）, While doing my own research , You need to prepare for this course from scratch , The amount of reading per week is huge , I admire it very much .”

Later, it seemed that there were only six 、 Seven people finished the course from beginning to end , There was a man who couldn't finish his homework , If you take the initiative, you will get zero points .

Undergraduate and graduate students from Peking University and Tsinghua university can offer more difficult courses than graduate schools of famous American universities 、 A course of great help to students , Let us see hope for the future 、 Increased confidence .

Zhou Chuan was a graduate student in China , Often participate in international academic activities .2006 year , He went to Hong Kong to participate in the second year of graduate school “ Molecular and cellular neurobiology Gordon meeting ”.2008 year , He went to Cold Spring Harbor Laboratory in the United States to participate in “ Advanced technology of molecular neuroscience ” Summer school .2009 year , He joined Cold Spring Harbor “ Drosophila neurobiology conference ”, And exchange their original research , I also went to the postdoctoral laboratory .

2009 year , Zhou Chuan and Zhang Yi returned from New York after their meeting in Cold Spring Harbor , When I stopped in Chicago, I happened to return home by the same plane

2009 year , Zhou Chuan won the outstanding graduate award of Beisheng University , In the same year, he won the first wurui Award for national excellent graduate students in biology .

Zhou Chuan won the first wurui scholarship

Zhou Zhuan is very humorous 、 Can unite people , Mobilize the laboratory atmosphere 、 Agglutinate classmates . There are many activities in the early years of my laboratory , It is often initiated by Zhou Chuan , So the lab is fun . When he returned home , Sometimes I also initiate activities in my laboratory .

Libingfeng recalled ：

 “ Zhou Chuan's ambition is elegant , Like calligraphy 、 tourism , I especially like classical music , Although the level of violin playing is average , But the appreciation of classical music is very tasteful , He can often name a piece of classical music very clearly 、 author 、 command 、 Player and version , And has a critical aesthetic preference , Like Beethoven's Ninth Symphony , He admires Karajan most 1963 Year version of —— Although Bernstein 1989 The version in may be better known .

He also likes to discuss science with people , Also very tasteful , Be able to think from a historical perspective , So as to make a concise and comprehensive evaluation of others' work , My favorite mantra is insight（ Insight ） and trivial（ not worth mentioning ）.

I think the study of nerves , It's hard not to be interested in psychology and Sociology ; He and I have read a lot of these two subjects at the same time “ Idle reading ”, There are many common topics .

When I worked with Zhou Chuan , One of my favorite things is to accompany him with classical music , Overnight discussion of academic issues , In other words, it is a question of wisdom . People are born lonely , Meet this confidant , be the most supreme .”

2010 After graduating from my laboratory in , Zhou Chuan went to America HHMI Of Janelia To be a postdoctoral . stay Bruce Baker Laboratory studies on courtship behavior of Drosophila melanogaster , Published three papers , He is the corresponding author of one of the original research papers .

Zhou Zhuan, a postdoctoral student in the United States

Zhou Chuan took a group photo with his classmates in the United States

Zhou Chuan was a postdoctoral student in the United States Baker laboratory

While in my lab , Zhou Chuan met a Peking University undergraduate . After graduation, she went to graduate school in the United States , I also published my first paper in Nature Neuroscience. Although they were separated from each other , But successfully married .

2015 year , Zhou Chuan joined the Institute of zoology as a researcher through the talent introduction program of the Chinese Academy of Sciences , Start leading independent laboratories . For Zhou Chuan , Independence is easy , Because he was in my lab and Baker The laboratories are very creative , Don't rely on teachers .

Zhou Chuan laboratory, Institute of zoology, Chinese Academy of Sciences

After returning , Zhou Chuan soon decided not only to be a fruit fly 、 Also started studying mosquitoes , Using modern molecular biology and genetics to study mosquitoes .2016 year , He won the National Science Fund for outstanding young people .2018 year , Zhou Chuan won the first hundred talents plan of the Academy of Sciences .

However , When his career is sailing , Zhou Chuan was diagnosed with illness .

Because the prognosis of the disease is poor 、 Great side effects , Zhou Chuan decided not to treat , In order to have more “ health ” Time for .

During illness , He insisted on scientific research . After blindness , Have to go through 17 Hours of surgery . But he continued to direct the research in the laboratory , Communicate with students , Until it is completely impossible . Sometimes a wife and mother are required to record . After his serious illness , He led the laboratory to publish an original research paper （Wu et al., 2020）、 The student received a doctorate . Zhou Chuan's lab has two more articles in the process of submission （Wang et al.; Ma et al.）.

Zhou Chuan has a high degree of enthusiasm for science , Have a strong will for research work .

Zhou Chuan's wife , During the unfinished period of his studies, he separated from Zhou Chuan . But whether Zhou Chuan is healthy 、 Still sick , He has always insisted on his love and support for Zhou Chuan . But after Zhou Chuan fell ill, he was always on guard , Moving .

They are Peking University 、 Tsinghua can be proud of its ideals 、 An emotional student . They foreshadow the hope that our country will have successors in the future .

2022 year 2 month 13 Japan

Tsinghua University 2001 Class 1 of grade 1 and students of Beijing Institute of life sciences mourned Zhou Zhuan

Chuan Zhou, Yong Rao, Yi Rao (2008). The Neurotransmitter Octopamine is Essential for Aggression in Drosophila. Nature Neuroscience 11:1059-67

Chuan Zhou, Hai Huang, Susy M. Kim, Hsuanwen Lin, Xianglan Meng, Kyung-An Han, Ann-Shyn Chiang, Jing W. Wang, Renjie Jiao, and Yi Rao (2012). Molecular Genetic Analysis of Sexual Rejection: Roles of Octopamine and Its Receptor OAMB in Drosophila Courtship Conditioning. Journal of Neuroscience 32:14281-14287.

Xinhua Liang, Yi Rao and Chuan Zhou# (2014). The Neuronal Basis of How Sexual Experience Modulates Male Aggression. National Science Review 1:473-474 (#corresponding author)

Alexander G. Vaughan, Chuan Zhou, Devanand S. Manoli, Bruce S. Baker (2014). Neural Pathways for the Detection and Discrimination of Conspecific Song in D. melanogaster. Current Biology 24:1039–1049

Chuan Zhou, Carmen C. Robinett, Geoffrey W. Meissner, and Bruce S. Baker (2014). Central Brain Neurons Expressing doublesex Regulate Female Receptivity in Drosophila. Neuron 83:149-63.

Chuan Zhou#, Romain Franconville, Alexander G. Vaughan, Vivek Jayaraman and Bruce Baker# (2015). Central Neural Circuitry Mediating Courtship Song Perception in Male Drosophila. Elife 4:e08477 (#corresponding author).

Fengming Wu, Bowen Deng, Na Xiao, Tao Wang, Yining Li, Rencong Wang, Kai Shi, Dong-Gen Luo, Yi Rao and Chuan Zhou (2020). A neuropeptide regulates fighting behavior in Drosophila melanogaster. Elife 9:e54229. Doi:10.7554/elife.54229.

Wang T, Jing BY, Deng BW, Shi K, Li J, Ma BX, Wu FM#, Chuan Zhou#. Drosulfakinin signaling modulates female sexual receptivity in Drosophila. (under review) (#corresponding author)

Ma BX, Wang RC, Deng BW, Liu YH, Wang T, Wu FM#, Chuan Zhou#. Serotonin signal modulates female sexual receptivity in Drosophila. (under review) (#corresponding author) 

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