Study on bifunctional crosslinker lumiprobe sulfoacyanine 7 dicarboxylic acid

AI Meijie Lumiprobe Sulfo-Cyanine7  Dicarboxylic acid （Сy7  Analogues ） It is a water-soluble double function  NIR  Dye derivatives , With two carboxylic acid functional groups .

AI Meijie  Lumiprobe   Sulfo cyanine 7 Chemical properties of dicarboxylic acid ：

form ： Dark green solid

Molecular weight ：847.09

Molecular formula ：C 42 H 51 N 2 KO 10 S 2

solubility ： dissolve in water 、DMF、DMSO

The quality control ：NMR 1 H, HPLC-MS (95%)

Storage conditions ： Store ： stay  -20°C  Keep away from light . transport ： At room temperature for  3  Zhou . Avoid prolonged exposure to light . dry .

AI Meijie Lumiprobe  Sulfo cyanine 7 Spectral properties of dicarboxylic acids ：

The greatest inspiration / absorption ,nm： 750

ε, L⋅mol -1 ⋅cm -1： 240600

The largest launch , nanometer ： 773

Fluorescence quantum yield ： 0.24

CF 260： 0.04

CF 280： 0.04.

AI Meijie Lumiprobe  Sulfo cyanine 7 Research on dicarboxylic acid ：

Sulfo-Cyanine7.5  Dicarboxylic acid

Sulfo-Cyanine7.5  Dicarboxylic acid is a kind of acid with two carboxylic acids  (COOH)  A bifunctional cyanine dye with a radical . The molecule can be used to construct cross coupling compounds containing near-infrared emitting fluorophores .

Sulfo-Cyanine5  double -NHS  ester

There are two  NHS  Water soluble amine activity of ester groups  Cyanine5  dyestuff .

Pentenoic acid STP ester

Used to introduce alkynes into peptides / Activated esters of proteins .

PEG3- Dicarboxylic acid

PEG3-D Dicarboxylic acid is a kind of bifunctional joint with two carboxyl groups . It contains a polyethylene glycol between carboxyl groups -3  Joint .

iodine -PEG3- Iodide

Based on the same bifunction with halogen reaction group  PEG3  The linker can be used for the crosslinking of nucleophiles .