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核酸修饰的金属有机框架药物载体|PCN-223金属有机骨架包载Ad金刚烷|ZIF-8包裹阿霉素(DOX)
2022-07-03 13:24:00 【qiyueshengwu】
核酸修饰的金属有机框架药物载体;PCN-223金属有机骨架包载Ad金刚烷;ZIF-8包裹阿霉素(DOX)
通常,药物通过原位封装或合成后修饰策略负载到MOFs中。前者是一种相对简单的方法,适用于热稳定药物克服药物的过早释放。后者为避免破坏药物分子提供了更温和的环境。随着MOF化学的发展,已经探索了一系列MOFs作为在该领域中应用的有前途的候选载体。

ZIF-8包裹阿霉素(DOX)的介绍
利用金属-有机框架材料ZIF-8包裹二硫化钼(MoS2)纳米片和阿霉素(DOX)构建一种可通过酸性pH和近红外(NIR)光双触发的肿瘤化学/光热体系,
方法:首先,通过水热反应和超声处理制备粒径为~100nm,厚度为0.3~1.4nm的MoS2纳米片.然后,通过一步法将可酸降解的金属-有机框架ZIF-8包裹在所制备的MoS2纳米片上,并同时装载药物DOX,形成装载DOX的ZIF-8包裹MoS2纳米复合物(DOX/[email protected])。
脂质体修饰的铁基金属有机框架纳米药物[email protected]OF-Lip
环糊精金属有机骨架材料(CD-MOFs)包载大黄素
环糊精金属有机骨架材料(CD-MOFs)包载槲皮素
阿魏酸/钾/β-环糊精金属有机骨架包合物(FA/K/β-CD/MOF),
环糊精金属有机骨架材料(CDMOFs)装载三氯蔗糖
环糊精金属有机骨架材料(CDMOFs)装载二氟尼柳
环糊精金属有机骨架材料(CDMOFs)负载奥美拉唑(OME)
叶酸配体的金属有机骨架MOFs材料负载5-氟尿嘧啶
叶酸配体的金属有机骨架MOFs材料负载西达本胺
叶酸配体的金属有机骨架MOFs材料负载紫杉醇
叶酸配体的金属有机骨架MOFs材料负载阿霉素
叶酸配体的金属有机骨架MOFs材料负载柔红霉素等药物
以上资料来自小编axc,2022.06.15
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