Metal organic framework materials (fe-mil-53, mg-mof-74, ti-kumof-1, fe-mil-100, fe-mil-101) supported on isoflurane / methotrexate / doxorubicin (DOX) / paclitaxel / ibuprofen / camptothecin

Metal organic framework materials Fe-MIL-53,Mg-MOF-74,Ti-KUMOF-1,Fe-MIL-100,Fe-MIL-101) Loaded isoflurane / Methotrexate / Adriamycin (DOX)/ Paclitaxel / Ibuprofen / Camptothecin

Using the grand canonical Monte Carlo method , To new halogenated hydroxyalkanes -- Isoflurane in metals - Organic skeleton materials (MOFs) The load performance of the . Select including Fe,Mg and Ti Equal to the metal center 5 A kind of good biocompatibility MOFs Conduct research , The results show that under normal pressure , The material with larger pore volume has larger loading capacity of isoflurane , And Fe-MIL-101 High load , Loadable equivalent to its own mass 2 Times the drug . Through radial distribution function and configuration analysis, it is found that , The main forces of drug loading are hydrogen bonds and metals - Drug interactions . The isokinetic analysis shows that ,Fe-MIL-53 and Mg-MOF-74 Strong adsorption energy ,

Fe-MIL-53 Loaded isoflurane

Mg-MOF-74 Loaded isoflurane

Ti-KUMOF-1 Loaded isoflurane

Fe-MIL-100 Loaded isoflurane

Fe-MIL-101 Loaded isoflurane

 

Service one 、 Metal organic framework Fe-MIL-53 Loaded methotrexate , Adriamycin (DOX), Paclitaxel , Ibuprofen , Camptothecin , Curcumin , Small molecule drugs such as gambogic acid

Service two 、 Metal organic framework materials Mg-MOF-74 Carboxybenzyl penicillin encapsulated ,MTX Methotrexate , Paclitaxel PTX, Adriamycin DOX, Cisplatin CDDP,CPT Camptothecin and other drugs

Service 3 、 Metal organic framework Ti-KUMOF-1 Loading ciprofloxacin , Metronidazole , Letitrexed , Pemetrexed , Anisamide ,Ad Adamantane , Azithromycin and other drugs

Service 4 、 Metal organic framework materials Fe-MIL-100 Encapsulated fluorouracil , Mercaptopurine , Adriamycin hydrochloride , Lansoprazole , Thymol , Oridonin , Cinnamic acid and other drugs

Service 5 、 Metal organic framework Fe-MIL-101 Loaded oleanolic acid , Siduofoway , Cantharidin gas , Procainamide hydrochloride , Non steroidal drugs

Service six 、 Metal organic framework materials UIO-66-COOH Containing meloxicam , Celecoxib in , nimesulide , aspirin , Acetaminophen , Indomethacin and other drugs

The above information comes from Xiaobian axc,2022.06.10