中英文说明书丨ProSci LAG-3 重组蛋白

靶向抑制性协同受体PD-1和CTLA-4的检查点免疫疗法彻底改变了癌症治疗，而LAG-3作为新一代发现的抑制性检查点，有望成为肿瘤治疗中J具前景的靶点。

艾美捷ProSci LAG-3 重组蛋白的化学性质：

英文名称：LAG-3 Recombinant Protein

cat#：PSI-90-241

规格：50ug

来源宿主：CHO 细胞

溶解建议：开盖前，先离心。建议按说明书中要求的方式进行溶解和使用。

保存建议：Stable for at least 6 months after receipt when stored at -20˚C.

物种：人类

来源物种：人体细胞

重组蛋白序列：Leu23-Gly434

融合标签：C-6 his标签

艾美捷ProSci LAG-3 重组蛋白可以应用于已测试验证过的应用类型。

 

Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.

Specications：

Species Human, Monkey, Mouse

Source Species CHO cells

Fusion Tag Fc Tag

Biological Activity

Inhibits binding of MAb to LAG-3 (human) to LAG-3. Induces maturation of human dendritic

cells.

Properties：

Purity

>99% (SDS-PAGE).<br><br> Endotoxin level is less than 0.1EU/ μg puried protein (LAL test;

Lonza).

Physical State Liquid

Buer In PBS.

Concentration 0.5 mg/ml

Storage Conditions Stable for at least 6 months after receipt when stored at -20°C.