Nat. Comm. | supercomputing +ai: providing navigation for natural product biosynthesis route planning

Natural products (Natural Products) It is the main source of clinical drug development , Analyzing the biosynthetic pathway of natural products is the most basic step in realizing biosynthesis . However , At present, more than 90% The biosynthetic pathway of natural products of is still unknown . The research group of Professor wuruibo of the school of pharmacy of Sun Yat sen University and the research group of Professor yangyuedong of the National Supercomputing Center in Guangzhou are jointly engaged in star pharmaceutical science and technology 、 Massachusetts Institute of technology and Georgia Institute of technology , Depending on the “ Tianhe no.2 ” A deep learning based navigator for natural product biosynthesis pathway has been developed BioNavi-NP, And has been well verified in several public test sets , It's supercomputing +AI Another practice of scientific and technological innovation . The study found the biogenic pathway of natural products , And the reconstruction of heterologous biosynthesis pathway is of great significance . Related achievements 6 In June, it was officially published in the international well-known journal 《Nature Communication》.

Thesis link ：

https://www.nature.com/articles/s41467-022-30970-9

BioNavi-NP Website links ：

http://biopathnavi.qmclab.com/