Nat. Comm. | use tensor cell2cell to deconvolute cell communication with environmental awareness

This paper introduces the Department of bioengineering at the University of California, San Diego Nathan E. Lewis Newsletter published on Nature Communications Research results of ： The author introduces Tensor-cell2cell, This is an unsupervised method based on tensor decomposition , It explains multiple stages of cells at the same time 、 State or location to decipher context driven intercellular communication . So ,Tensor-cell2cell It is revealed that it is related to different phenotypic states and is determined by cell types and ligands - The unique combination of receptor pairs determines the context driven communication mode .Tensor-cell2cell It effectively improves and expands the analysis ability of existing tools . The author found ,Tensor-cell2cell It can identify multiple modules related to the obvious communication process , These communication processes are related to COVID-19 Severity is associated with autism spectrum disorders . therefore , The author introduces an effective and easy-to-use strategy to understand complex communication modes under different conditions .

Thesis link ：

https://www.nature.com/articles/s41467-022-31369-2

data ：

https://doi.org/10.24433/CO.0051950.v2

Code ：

https://doi.org/10.24433/CO.0051950.v2 http://lewislab.ucsd.edu/cell2cell/