Folic acid modified metal organic framework (zif-8) baicalin loaded metal organic framework composite magnetic material (AU- [email

Folic acid modified metal - Organic skeleton （ZIF-8） Baicalin loaded | Metal organic skeleton composite magnetic material ([email protected])| Preparation route

With zeolite imidazole ester framework （ZIF-8） As a carrier , Folate receptor （PEG-FA） Responsive baicalin nano delivery system [email protected]@BAN, It turns out that [email protected]@BAN Nano drug loading system has good dispersibility , Baicalin loading efficiency is as high as 41.45±1.43%, The hydrated particle size is 176±8.1nm,Zeta The potential is -23.83±1.1mV, In an acidic environment （pH=5.0） Chinese medicine is slowly released in large quantities and in a neutral environment （pH=7.4） The medium release amount is 11.03%.

 

Common nano drug carriers

Nano drug carriers generally need to meet the following conditions ：

1) Small size , It can be ingested by cancer cells ;

2) High load ,

3) Good surface properties , The pharmacokinetic properties were improved , Good biocompatibility ,

4) It can improve the absorption of drugs by cells 、 Prolong the action time of drugs in the body, and so on . Nano drug carriers can be divided into the following categories according to their shapes ： Nanocapsule 、 Nanoparticles 、 Nano gel 、 Nano microspheres, etc .

Nucleic acid functionalization UiO-66 NMOF Loading adriamycin DOX

Nucleic acid functionalization UiO-66 NMOF Camptothecin loaded CPT

MOFs Loaded lactic acid - Glycolic acid (PLGA) Nanofibers

Quercetin labeled metal organic framework (Zr-MOF)

Folic acid ligand MOFs Material loaded sidabelamine

Folic acid ligand MOFs Material loaded paclitaxel

Folic acid ligand MOFs Material loaded adriamycin

Folic acid ligand MOFs Material loaded daunorubicin

[email protected]@HAp Loading anticancer drug adriamycin hydrochloride (DOX),

Iron based metal organic framework nano drugs [email protected]

The above information comes from Xiaobian axc,2022.06.15