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反絮凝剂-氨碘肽滴眼液
2022-07-05 03:35:00 【微电子学与固体电子学-俞驰】
玻璃体混浊的成分是II型胶原蛋白纤维,原本外面又一层IX型胶原蛋白,IX外面有一层硫酸软骨素侧链。
由于硫酸软骨素侧链受到自由基(自由基来自视网膜处理光信号后排泄到玻璃体中)的攻击,丢失,IX也随着丢失,此时II型裸露,
II型由于具备较强的粘性,发生聚沉效应(也称为“絮凝效应”)
因此析出形成我们眼中的“飞蚊”。
既然有絮凝剂,也就有所谓的反絮凝剂,但是很遗憾的是只有食品工业的人在关注胶原蛋白和絮凝剂,反絮凝剂即使在食品工业也少有人问津。
因此:
①玻璃体混浊(也就是飞蚊症)最大的问题在于,找不到“反絮凝剂”。
这个事情需要多学科配合,才能让飞蚊再次溶解消失不见。
也就是说需要一种“反絮凝剂”眼药水,让聚沉的II型胶原蛋白"解聚",才能再次溶解。
②FOV手术去除会100%导致白内障加速提前,激光消融如果不慎打到眼底那就终生黑点。
总是有人想挑战②中这两个生活常识。
事实是临床医学和基础医学在这个问题上,真的是十分割裂的,互相不理解。
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氨碘肽滴眼液的发明者真的是神人,深藏功与名。
从目前我接触到的患者来看,这个东西极有可能是一种反絮凝剂:
解散玻璃体混浊,让浑浊物散开,再次溶解在玻璃体中。
但是呢,对于已经打结的浑浊物,效果可能不会好。
所以可以进行尝试,尝试时间不需要超过2个月,如果没有任何缓解效果,可以放弃。
如果有缓解效果,可以持续滴,有较大可能全部溶解,消失不见。
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