GEO数据库中搜索数据

GEO数据库https://www.ncbi.nlm.nih.gov/gds/

GEO DataSets和GEO Profiles是NCBI的Entrez数据库网络的一部分。与这些其他数据库一样，只需在GEO DataSets或GEO Profiles的搜索框中输入关键词，就可以找到感兴趣的数据。在GEO DataSets和GEO Profiles页面头部链接的高级搜索和限制页面，对复杂查询的构建有很大帮助。要构建一个复杂的查询，指定搜索条件、它们的字段，以及使用以下语法对条件进行布尔运算。

term [field] OPERATOR term [field]

注：OPERATOR is the Boolean operator ('AND', 'OR', 'NOT' must be capitalized).

常用字段为：
All Fields，Title，MeSH Terms，Description，Number of Samples，Supplementary Files，Update Date，GEO Accession，Organism

Search Examples:

Search by...	Search text
Free text	smoking cancer
Keywords and species	(smok* OR diet) AND (mammals[organism] NOT human[organism])
Studies in the NIH Roadmap Epigenomics project	"roadmap epigenomics"[Project]
Study type	"expression profiling by high throughput sequencing"[DataSet Type]
Studies with between 100 and 500 samples	100:500[Number of Samples]
Studies with CEL files	"cel"[Supplementary Files]
DataSets that have 'age' as an experimental variable	"age"[Subset Variable Type]
Author	smith a[Author]
Published between January and June 2007	2007/01:2007/06[Publication Date]
Platform accession	GPL570
Studies with PubMed identifiers	"gds pubmed"[Filter]

关于MeSH  https://www.nlm.nih.gov/mesh/meshhome.html

例子

gastric tumor[MeSH] 

gastric tumor[Title] 

gastric tumor[Title] AND Homo sapiens[Organism] 

Colorectal Neoplasms[MeSH]

Colorectal Neoplasms[MeSH] AND Homo sapiens[Organism] 

Colorectal Neoplasms[MeSH] AND Homo sapiens[Organism] AND 100:500[Number of Samples] AND 

Colorectal cancer[All Fields] AND Homo sapiens[Organism] 

Colorectal cancer[MeSH  Terms] AND "Homo sapiens"[Organism] 

(survival OR prognosis OR prognostic OR outcome OR death OR relapse OR recurrence) AND Colorectal Neoplasms[MeSH] AND Homo sapiens[Organism] AND (metastatic OR metastasis) AND 10:10000[Number of Samples] AND GPL570[Related Series]

Colorectal Neoplasms[MeSH] AND immunotherapy[Title] 

Colorectal Neoplasms[MeSH] AND primary[Title] 

Colorectal Neoplasms[MeSH] AND primary[metastatic]  

(intestinal polyps[MeSH] OR Colorectal Neoplasms[MeSH]) AND Homo sapiens[Organism] AND primary[Title] AND AND 10:10000[Number of Samples] 

参考

https://www.ncbi.nlm.nih.gov/geo/info/qqtutorial.html