For friends who are not fat at all, nature tells you the reason: it is a genetic mutation

Yi Pavilion From the Aofei temple qubits | official account QbitAI

Are there any friends around you who don't get fat anyway ？

Even if you eat the sea jam , Don't exercise , It can also easily maintain a slim figure ？

World's top academic journals Nature A newly published paper , It reveals these people 2%-4% Of “ Born thin ” The genetic secret of .

Studies have shown that , A name is Inosine （inosine） Metabolites of can accelerate fat burning .

In the mouse experiment , If mice are fed a high-energy diet and supplemented with inosine , Will become “ Don't eat fat ” The type of , It can also avoid the risk of diabetes .

To understand how inosine produces this magical effect , We need to introduce a special kind of fat first .

Fat, too “ good “ fat ？

Fat in the human body is divided into white fat and brown fat .

The former is the kind of fat we usually know , It is widely distributed around subcutaneous tissue and viscera , Its function is to store excess energy in the form of fat ;

The function of brown fat is to convert the energy in food into heat energy through a large number of mitochondria in its cells , In short , Is to burn yourself 、 Heating the body .

△ Brown fat

therefore , Activate brown fat “ good ” fat 、 Increasing fat burning has become the goal of researchers .

But it's not easy .

One of the authors 、 Professor, University of Bonn Alexander Pfeifer Pointed out that ：

Now , Even in winter , We are also very warm . therefore , We “ The stove in the body ” No longer needed .

meanwhile , We eat more and more food 、 But less and less exercise .

These three factors can be fatal to brown fat cells ： Their functions will gradually disappear , Even eventually die .

Now , Inosine is needed to function .

“ Inosine ”： Fat burning accelerator

as everyone knows , Dying cells release a mixture of messenger molecules that affect the function of their neighbors .

To study whether this mechanism also exists in brown fat , Researchers looked at dying brown fat cells , It is found that they are secreting a large number of substances called “ Inosine ” Metabolites of .

More interesting , These inosine secreted , It can not only activate the surrounding healthy brown fat cells , Increase energy consumption , It can also induce white adipose tissue “ Browning ” Brown fat .

It's killing two birds with one stone .

But it can be called “ Fat burning accelerator ” Inosine also has a bad time .

The presence of inosine transporters , Deliver inosine into cells , It reduces the concentration of extracellular inosine , Therefore, inosine can no longer play its role in promoting fat burning .

The interesting thing is , Some people can rely on their own genes to inhibit the production of inosine transporters .

Researchers at the University of Leipzig are right 900 Several volunteers conducted genetic analysis , Results show , There are... In the crowd 2% To 4% People who , Due to genetic variation , Transporters are less active , And these people are much thinner than others .

Human intervention “ Inosine ” Is it reliable ？

In addition to this innate genetic advantage , Researchers tried to put a drug originally developed for coagulation disorders , For inhibiting the production of inosine transporters , It has an immediate effect —— With the increase of extracellular inosine concentration , Brown fat starts to burn .

Take this drug as the starting point , Researchers are trying to develop other specialized drugs , To inhibit the growth of transporters , This research result may be applicable to the treatment of obesity .

But Professor of Bonn University Alexander Pfeifer Express , The global spread of obesity will not be solved by a single pill , We also need further research to normalize the energy balance of obese patients .

Reference link ： [1]https://www.news-medical.net/news/20220705/Study-identifies-a-molecule-that-boosts-fat-burning.aspx [2]https://www.nature.com/articles/s41586-022-05041-0

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